5h7p

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==NMR structure of the Vta1NTD-Did2(176-204) complex==
==NMR structure of the Vta1NTD-Did2(176-204) complex==
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<StructureSection load='5h7p' size='340' side='right' caption='[[5h7p]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='5h7p' size='340' side='right'caption='[[5h7p]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h7p]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H7P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h7p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H7P FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7p OCA], [http://pdbe.org/5h7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h7p RCSB], [http://www.ebi.ac.uk/pdbsum/5h7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7p ProSAT]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h7p OCA], [https://pdbe.org/5h7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h7p RCSB], [https://www.ebi.ac.uk/pdbsum/5h7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h7p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST]] Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>PMID:12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref> <ref>PMID:16601096</ref> [[http://www.uniprot.org/uniprot/DID2_YEAST DID2_YEAST]] Class E VPS protein implicated in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. The lumenal sequestrated membrane proteins will be targeted into the vacuole after fusion of the endosome with the vacuole. Probably acts as a peripherally associated component of the ESCRT-III complex, which appears to be critical for late steps in MVB sorting, such as membrane invagination and final cargo sorting and recruits late-acting components of the sorting machinery. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complex assemblies. Regulates the membrane association of VPS4. Can stimulate VPS4 ATPase activity directly or via VTA1.<ref>PMID:11029042</ref> <ref>PMID:11559748</ref> <ref>PMID:15086794</ref> <ref>PMID:16601096</ref> <ref>PMID:17130288</ref> <ref>PMID:18032584</ref> <ref>PMID:18194652</ref>
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[https://www.uniprot.org/uniprot/VTA1_YEAST VTA1_YEAST] Has a role in the formation of the multivesicular body (MVB). Required for the sorting of lipids to form intralumenal vesicles and for fluid-phase transport to the vacuole. Required for sorting the plasma membrane proteins STE2 and STE3 into the MVB. Acts a cofactor of VSP4, promotes the oligomerization of VPS4 and stimulates its ATPase activity by 6- to 8-fold.<ref>PMID:12953057</ref> <ref>PMID:14701806</ref> <ref>PMID:16505166</ref> <ref>PMID:16601096</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5h7p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5h7p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shen, J]]
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[[Category: Large Structures]]
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[[Category: Wild, C J]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Yang, Z]]
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[[Category: Shen J]]
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[[Category: Endosomal sorting complexes required for transport]]
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[[Category: Wild CJ]]
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[[Category: Multivesicular body]]
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[[Category: Yang Z]]
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[[Category: Protein transport]]
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[[Category: Saccharomyces cerevisiae protein]]
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Current revision

NMR structure of the Vta1NTD-Did2(176-204) complex

PDB ID 5h7p

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