1r3m

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[[Image:1r3m.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease==
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|PDB= 1r3m |SIZE=350|CAPTION= <scene name='initialview01'>1r3m</scene>, resolution 2.2&Aring;
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<StructureSection load='1r3m' size='340' side='right'caption='[[1r3m]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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<table><tr><td colspan='2'>[[1r3m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R3M FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r3m OCA], [https://pdbe.org/1r3m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r3m RCSB], [https://www.ebi.ac.uk/pdbsum/1r3m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r3m ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1bsr|1BSR]], [[1r5c|1R5C]], [[1r5d|1R5D]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r3m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r3m OCA], [http://www.ebi.ac.uk/pdbsum/1r3m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r3m RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RNS_BOVIN RNS_BOVIN] This enzyme hydrolyzes both single- and double-stranded RNA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r3/1r3m_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r3m ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state.
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'''Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease'''
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Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease.,Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L FEBS Lett. 2003 Nov 6;554(1-2):105-10. PMID:14596923<ref>PMID:14596923</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1r3m" style="background-color:#fffaf0;"></div>
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==Overview==
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==See Also==
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Bovine seminal ribonuclease is a unique case of protein dimorphism, since it exists in two dimeric forms, with different biological and kinetic behavior, which interconvert into one another through three-dimensional swapping. Here we report the crystal structure, at 2.2 A resolution, of the unswapped form of bovine seminal ribonuclease. Besides completing the structural definition of bovine seminal ribonuclease conformational dimorphism, this study provides the structural basis to explain the dependence of the enzyme cooperative effects on its swapping state.
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*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1R3M is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R3M OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease., Berisio R, Sica F, De Lorenzo C, Di Fiore A, Piccoli R, Zagari A, Mazzarella L, FEBS Lett. 2003 Nov 6;554(1-2):105-10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14596923 14596923]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Pancreatic ribonuclease]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Berisio R]]
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[[Category: Berisio, R.]]
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[[Category: De Lorenzo C]]
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[[Category: Fiore, A Di.]]
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[[Category: Di Fiore A]]
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[[Category: Lorenzo, C De.]]
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[[Category: Mazzarella L]]
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[[Category: Mazzarella, L.]]
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[[Category: Piccoli R]]
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[[Category: Piccoli, R.]]
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[[Category: Sica F]]
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[[Category: Sica, F.]]
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[[Category: Zagari A]]
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[[Category: Zagari, A.]]
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[[Category: hinge]]
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[[Category: ribonuclease]]
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[[Category: swapping]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:22:43 2008''
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Current revision

Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease

PDB ID 1r3m

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