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| - | | + | #REDIRECT [[7ssj]] This PDB entry is obsolete and replaced by 7ssj |
| - | ==Crystal structure of the DesK-DesR complex in the phosphatase state==
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| - | <StructureSection load='5iun' size='340' side='right' caption='[[5iun]], [[Resolution|resolution]] 2.79Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5iun]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IUN FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACP:PHOSPHOMETHYLPHOSPHONIC+ACID+ADENYLATE+ESTER'>ACP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iuj|5iuj]], [[5iuk|5iuk]], [[5iul|5iul]], [[5ium|5ium]]</td></tr>
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| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5iun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5iun OCA], [http://pdbe.org/5iun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5iun RCSB], [http://www.ebi.ac.uk/pdbsum/5iun PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5iun ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/DESK_BACSU DESK_BACSU]] Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates DesR by phosphorylation.<ref>PMID:11285232</ref> <ref>PMID:11717295</ref> <ref>PMID:12207704</ref> <ref>PMID:14734164</ref> <ref>PMID:15090506</ref> [[http://www.uniprot.org/uniprot/DESR_BACSU DESR_BACSU]] Member of the two-component regulatory system DesR/DesK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase.<ref>PMID:11285232</ref> <ref>PMID:11717295</ref> <ref>PMID:12207704</ref> <ref>PMID:14734164</ref> <ref>PMID:15090506</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Histidine kinase]]
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| - | [[Category: Buschiazzo, A]]
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| - | [[Category: Imelio, J A]]
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| - | [[Category: Larrieux, N]]
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| - | [[Category: Trajtenberg, F]]
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| - | [[Category: Dephosphorylation]]
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| - | [[Category: Kinase]]
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| - | [[Category: Phosphatase complex]]
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| - | [[Category: Response regulator]]
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| - | [[Category: Transferase]]
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| - | [[Category: Transferase-gene regulation complex]]
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| - | [[Category: Two-component regulatory system]]
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