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4g1p
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==Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae== | ==Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae== | ||
| - | <StructureSection load='4g1p' size='340' side='right' caption='[[4g1p]], [[Resolution|resolution]] 2.55Å' scene=''> | + | <StructureSection load='4g1p' size='340' side='right'caption='[[4g1p]], [[Resolution|resolution]] 2.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4g1p]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4g1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4G1P FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.547Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CYS:CYSTEINE'>CYS</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4g1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4g1p OCA], [https://pdbe.org/4g1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4g1p RCSB], [https://www.ebi.ac.uk/pdbsum/4g1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4g1p ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DUG1_YEAST DUG1_YEAST] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.<ref>PMID:17179087</ref> <ref>PMID:19346245</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Kumaran | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Mittal | + | [[Category: Kumaran S]] |
| - | [[Category: Pandya | + | [[Category: Mittal M]] |
| - | [[Category: Singh | + | [[Category: Pandya VK]] |
| - | [[Category: Singh | + | [[Category: Singh AK]] |
| - | [[Category: Singh | + | [[Category: Singh M]] |
| - | + | [[Category: Singh V]] | |
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Current revision
Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae
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