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4kqv

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==Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor==
==Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor==
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<StructureSection load='4kqv' size='340' side='right' caption='[[4kqv]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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<StructureSection load='4kqv' size='340' side='right'caption='[[4kqv]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kqv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Frath Frath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KQV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kqv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._holarctica_LVS Francisella tularensis subsp. holarctica LVS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KQV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KQV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hy1|4hy1]], [[4ksg|4ksg]], [[4ksh|4ksh]], [[4k4o|4k4o]], [[4kfg|4kfg]], [[4ktn|4ktn]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DOO:6-FLUORO-4-[(3AR,6AR)-HEXAHYDROPYRROLO[3,4-B]PYRROL-5(1H)-YL]-N-METHYL-2-[(2-METHYLPYRIMIDIN-5-YL)OXY]-9H-PYRIMIDO[4,5-B]INDOL-8-AMINE'>DOO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNA TOPOISOMERASE IV SUBUNIT B PARE, FTL_1726, FTL_1726; ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=376619 FRATH])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqv OCA], [https://pdbe.org/4kqv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kqv RCSB], [https://www.ebi.ac.uk/pdbsum/4kqv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqv ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kqv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kqv OCA], [http://pdbe.org/4kqv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kqv RCSB], [http://www.ebi.ac.uk/pdbsum/4kqv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kqv ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PARE_FRATH PARE_FRATH] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA (PubMed:23352267, PubMed:23294697, PubMed:24386374). Performs the decatenation events required during the replication of a circular DNA molecule.[HAMAP-Rule:MF_00938]<ref>PMID:23352267</ref> <ref>PMID:24386374</ref> <ref>PMID:23294697</ref>
==See Also==
==See Also==
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*[[Topoisomerase|Topoisomerase]]
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Frath]]
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[[Category: Francisella tularensis subsp. holarctica LVS]]
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[[Category: Akers-Rodriguez, S]]
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[[Category: Large Structures]]
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[[Category: Bensen, D C]]
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[[Category: Akers-Rodriguez S]]
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[[Category: Lam, T]]
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[[Category: Bensen DC]]
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[[Category: Tari, L W]]
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[[Category: Lam T]]
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[[Category: Atp-binding]]
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[[Category: Tari LW]]
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[[Category: Atp-binding domain]]
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[[Category: Dna gyrase negatively supercoils closed circular double-stranded dna]]
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[[Category: Isomerase]]
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[[Category: Nucleotide-binding]]
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[[Category: Topoisomerase]]
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Current revision

Topoisomerase iv atp binding domain of francisella tularensis in complex with a small molecule inhibitor

PDB ID 4kqv

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