Phospholipase D
From Proteopedia
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(New page: <StructureSection load='1v0y' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Phospholipase D''' (PLD) hydrolyzes phosphatidylcholine (PC) into ...) |
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| - | + | <StructureSection load='' size='450' side='right' caption='Phospholipase D complex with substrate dibutyrylphosphatidylcholine (PDB code [[1v0y]])' scene='74/749398/Cv/1'> | |
| - | <StructureSection load=' | + | |
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== Function == | == Function == | ||
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== Structural highlights == | == Structural highlights == | ||
| + | The <scene name='74/749398/Cv/3'>active site of PLD contains the substrate derivative dibutyrylphosphatidylcholine</scene><ref>PMID:15165852</ref>. Water molecule are shown as red sphere. | ||
| + | ==3D structures of phospholipase D== | ||
| - | + | [[Phospholipase D 3D structures]] | |
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of phospholipase D== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[4rw3]] – bsPLD – brown spider<br /> | ||
| - | [[4rw5]] – bsPLD (mutant)<br /> | ||
| - | [[3rlg]], [[3rlh]] – PLD (mutant) – ''Loxosceles intemedia''<br /> | ||
| - | [[4q6x]] – PLD – cave spider<br /> | ||
| - | [[2ze4]], [[1v0r]], [[1v0s]], [[1f0i]] – SaPLD – ''Streptomyces antibioticus''<br /> | ||
| - | [[1v0v]], [[1v0w]] – SaPLD + phosphite<br /> | ||
| - | [[1v0y]] – SaPLD + phosphatidylcholine derivative<br /> | ||
| - | [[2ze9]] – SaPLD (mutant) + phosphatidylcholine<br /> | ||
| - | [[1v0t]], [[1v0u]] – SaPLD + glycerophosphate<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ McDermott M, Wakelam MJ, Morris AJ. Phospholipase D. Biochem Cell Biol. 2004 Feb;82(1):225-53. PMID:15052340 doi:http://dx.doi.org/10.1139/o03-079
- ↑ Oliveira TG, Di Paolo G. Phospholipase D in brain function and Alzheimer's disease. Biochim Biophys Acta. 2010 Aug;1801(8):799-805. doi:, 10.1016/j.bbalip.2010.04.004. Epub 2010 Apr 23. PMID:20399893 doi:http://dx.doi.org/10.1016/j.bbalip.2010.04.004
- ↑ Leiros I, McSweeney S, Hough E. The reaction mechanism of phospholipase D from Streptomyces sp. strain PMF. Snapshots along the reaction pathway reveal a pentacoordinate reaction intermediate and an unexpected final product. J Mol Biol. 2004 Jun 11;339(4):805-20. PMID:15165852 doi:http://dx.doi.org/10.1016/j.jmb.2004.04.003
