1r6f

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[[Image:1r6f.jpg|left|200px]]
 
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{{Structure
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==The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague==
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|PDB= 1r6f |SIZE=350|CAPTION= <scene name='initialview01'>1r6f</scene>, resolution 2.17&Aring;
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<StructureSection load='1r6f' size='340' side='right'caption='[[1r6f]], [[Resolution|resolution]] 2.17&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1r6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R6F FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6f OCA], [https://pdbe.org/1r6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r6f RCSB], [https://www.ebi.ac.uk/pdbsum/1r6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r6f ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r6f OCA], [http://www.ebi.ac.uk/pdbsum/1r6f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r6f RCSB]</span>
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[https://www.uniprot.org/uniprot/LCRV_YERPE LCRV_YERPE] Possibly involved in calcium regulation of YOP expression, which includes the export process.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r6/1r6f_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The LcrV protein (V-antigen) is a multifunctional virulence factor in Yersinia pestis, the causative agent of plague. LcrV regulates the translocation of cytotoxic effector proteins from the bacterium into the cytosol of mammalian cells via a type III secretion system, possesses antihost activities of its own, and is also an active and passive mediator of resistance to disease. Although a crystal structure of this protein has been actively sought for better understanding of its role in pathogenesis, the wild-type LcrV was found to be recalcitrant to crystallization. We employed a surface entropy reduction mutagenesis strategy to obtain crystals of LcrV that diffract to 2.2 A and determined its structure. The refined model reveals a dumbbell-like molecule with a novel fold that includes an unexpected coiled-coil motif, and provides a detailed three-dimensional roadmap for exploring structure-function relationships in this essential virulence determinant.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r6f ConSurf].
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1R6F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R6F OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague., Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS, Structure. 2004 Feb;12(2):301-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14962390 14962390]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Yersinia pestis]]
[[Category: Yersinia pestis]]
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[[Category: Derewenda, U.]]
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[[Category: Derewenda U]]
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[[Category: Derewenda, Z S.]]
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[[Category: Derewenda ZS]]
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[[Category: Devedjiev, Y.]]
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[[Category: Devedjiev Y]]
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[[Category: Evdokimov, A G.]]
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[[Category: Evdokimov AG]]
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[[Category: Mateja, A.]]
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[[Category: Mateja A]]
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[[Category: Routzahn, K M.]]
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[[Category: Routzahn KM]]
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[[Category: Waugh, D S.]]
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[[Category: Waugh DS]]
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[[Category: coiled-coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:23:53 2008''
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Current revision

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

PDB ID 1r6f

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