5l4h

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==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)==
==X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)==
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<StructureSection load='5l4h' size='340' side='right' caption='[[5l4h]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='5l4h' size='340' side='right'caption='[[5l4h]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l4h]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L4H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l4h]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Gloeobacter_violaceus_PCC_7421 Gloeobacter violaceus PCC 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L4H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6JW:5-(2-BROMOETHYL)-5-ETHYL-1,3-DIAZINANE-2,4,6-TRIONE'>6JW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4h OCA], [http://pdbe.org/5l4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l4h RCSB], [http://www.ebi.ac.uk/pdbsum/5l4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4h ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6JW:5-(2-BROMOETHYL)-5-ETHYL-1,3-DIAZINANE-2,4,6-TRIONE'>6JW</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l4h OCA], [https://pdbe.org/5l4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l4h RCSB], [https://www.ebi.ac.uk/pdbsum/5l4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l4h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI]] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
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[https://www.uniprot.org/uniprot/GLIC_GLOVI GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.<ref>PMID:17167423</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l4h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l4h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Delarue, M]]
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[[Category: Gloeobacter violaceus PCC 7421]]
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[[Category: Fourati, Z]]
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[[Category: Large Structures]]
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[[Category: Ruza, R R]]
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[[Category: Delarue M]]
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[[Category: Membrane protein]]
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[[Category: Fourati Z]]
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[[Category: Transport protein]]
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[[Category: Ruza RR]]

Current revision

X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with 5-(2-BROMO-ETHYL)-5-ETHYL-PYRIMIDINE-2,4,6-TRIONE (brominated barbiturate)

PDB ID 5l4h

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