1r7i

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[[Image:1r7i.gif|left|200px]]
 
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{{Structure
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==HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.==
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|PDB= 1r7i |SIZE=350|CAPTION= <scene name='initialview01'>1r7i</scene>, resolution 2.21&Aring;
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<StructureSection load='1r7i' size='340' side='right'caption='[[1r7i]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1r7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R7I FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydroxymethylglutaryl-CoA_reductase Hydroxymethylglutaryl-CoA reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.88 1.1.1.88] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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|GENE= MVAA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32044 Pseudomonas mevalonii])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7i OCA], [https://pdbe.org/1r7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r7i RCSB], [https://www.ebi.ac.uk/pdbsum/1r7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r7i ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1r31|1r31]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1r7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r7i OCA], [http://www.ebi.ac.uk/pdbsum/1r7i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1r7i RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/MVAA_PSEMV MVAA_PSEMV] P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r7/1r7i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r7i ConSurf].
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<div style="clear:both"></div>
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'''HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.'''
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==See Also==
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*[[HMG-CoA Reductase 3D structures|HMG-CoA Reductase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1R7I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_mevalonii Pseudomonas mevalonii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R7I OCA].
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[[Category: Large Structures]]
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[[Category: Hydroxymethylglutaryl-CoA reductase]]
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[[Category: Pseudomonas mevalonii]]
[[Category: Pseudomonas mevalonii]]
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[[Category: Single protein]]
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[[Category: Burgner JW]]
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[[Category: Burgner, J W.]]
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[[Category: Lawrence CM]]
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[[Category: Lawrence, C M.]]
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[[Category: Rodwell VW]]
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[[Category: Rodwell, V W.]]
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[[Category: Stauffacher CV]]
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[[Category: Stauffacher, C V.]]
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[[Category: Steussy CN]]
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[[Category: Steussy, C N.]]
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[[Category: Tabernero L]]
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[[Category: Tabernero, L.]]
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[[Category: Watson JM]]
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[[Category: Watson, J M.]]
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[[Category: 4-electron oxido-reductase]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:24:19 2008''
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Current revision

HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.

PDB ID 1r7i

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OCA

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