5ubl
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==A circularly permuted version of PvdQ (cpPvdQ)== | |
| - | + | <StructureSection load='5ubl' size='340' side='right'caption='[[5ubl]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ubl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UBL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ubl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ubl OCA], [https://pdbe.org/5ubl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ubl RCSB], [https://www.ebi.ac.uk/pdbsum/5ubl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ubl ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pseudomonas aeruginosa]] | ||
| + | [[Category: Catlin D]] | ||
| + | [[Category: Clevenger K]] | ||
| + | [[Category: Fast W]] | ||
| + | [[Category: Liu D]] | ||
| + | [[Category: Mascarenhas R]] | ||
| + | [[Category: Wu R]] | ||
Current revision
A circularly permuted version of PvdQ (cpPvdQ)
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