5m1z

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:20, 1 November 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR==
==STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR==
-
<StructureSection load='5m1z' size='340' side='right' caption='[[5m1z]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+
<StructureSection load='5m1z' size='340' side='right'caption='[[5m1z]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5m1z]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M1Z FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5m1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Fusarium_graminearum Fusarium graminearum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M1Z FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6LW:(2~{Z},3~{R},4~{R},5~{S})-2-HYDROXYIMINO-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL'>6LW</scene>, <scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-reducing_end_alpha-L-arabinofuranosidase Non-reducing end alpha-L-arabinofuranosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.55 3.2.1.55] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6LW:(2~{Z},3~{R},4~{R},5~{S})-2-HYDROXYIMINO-5-(HYDROXYMETHYL)OXOLANE-3,4-DIOL'>6LW</scene>, <scene name='pdbligand=AHR:ALPHA-L-ARABINOFURANOSE'>AHR</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1z OCA], [http://pdbe.org/5m1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m1z RCSB], [http://www.ebi.ac.uk/pdbsum/5m1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1z ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m1z OCA], [https://pdbe.org/5m1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m1z RCSB], [https://www.ebi.ac.uk/pdbsum/5m1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m1z ProSAT]</span></td></tr>
</table>
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/B8ZY56_GIBZA B8ZY56_GIBZA]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The synthesis of potent inhibitors of GH93 arabinanases as well as a synthesis of a chromogenic substrate to measure GH93 arabinanase activity is described. An insight into the reasons behind the potency of the inhibitors was gained through X-ray crystallographic analysis using the arabinanase Arb93A from Fusarium graminearum. These compounds lay a foundation for future inhibitor development as well as for the use of the chromogenic substrate in biochemical studies of GH93 arabinanases.
 +
 +
Exploiting sp2-hybridization in the development of potent 1,5-a-L-arabinanase inhibitors.,Coyle T, Debowski A, Varrot A, Stubbs KA Chembiochem. 2017 Mar 7. doi: 10.1002/cbic.201700073. PMID:28266777<ref>PMID:28266777</ref>
 +
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 5m1z" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Non-reducing end alpha-L-arabinofuranosidase]]
+
[[Category: Fusarium graminearum]]
-
[[Category: Varrot, A]]
+
[[Category: Large Structures]]
-
[[Category: Arabinofuramisodase]]
+
[[Category: Varrot A]]
-
[[Category: Complex]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Inhibitor]]
+

Current revision

STRUCTURE OF THE ALPHA-L-ARABINOFURANOSIDASE ARB93A FROM FUSARIUM GRAMINEARUM IN COMPLEX WITH AN hydroximolactone INHIBITOR

PDB ID 5m1z

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m1z"
Personal tools