3wsb

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==The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole==
==The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole==
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<StructureSection load='3wsb' size='340' side='right' caption='[[3wsb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3wsb' size='340' side='right'caption='[[3wsb]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3wsb]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WSB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3wsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi_strain_CL_Brener Trypanosoma cruzi strain CL Brener]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3WSB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wsa|3wsa]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPS:S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL]+TRIHYDROGEN+THIODIPHOSPHATE'>FPS</scene>, <scene name='pdbligand=RWZ:N-[(2Z)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-N-[(1R,3S,5R,7R)-TRICYCLO[3.3.1.1~3,7~]DEC-2-YL]ETHANE-1,2-DIAMINE'>RWZ</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene_synthase Squalene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.21 2.5.1.21] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsb OCA], [https://pdbe.org/3wsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3wsb RCSB], [https://www.ebi.ac.uk/pdbsum/3wsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wsb OCA], [http://pdbe.org/3wsb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3wsb RCSB], [http://www.ebi.ac.uk/pdbsum/3wsb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3wsb ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q4CWB4_TRYCC Q4CWB4_TRYCC]
==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Squalene synthase]]
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[[Category: Large Structures]]
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[[Category: Guo, R T]]
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[[Category: Trypanosoma cruzi strain CL Brener]]
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[[Category: Huang, C H]]
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[[Category: Guo RT]]
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[[Category: Li, Q]]
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[[Category: Huang CH]]
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[[Category: Oldfield, E]]
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[[Category: Li Q]]
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[[Category: Shang, N]]
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[[Category: Oldfield E]]
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[[Category: Drug discovery]]
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[[Category: Shang N]]
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[[Category: Fspp]]
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[[Category: Isoprenoid]]
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[[Category: Sq109]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Trypanosoma cruzi squalene synthase]]
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The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole

PDB ID 3wsb

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