4j4t

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==Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold==
==Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold==
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<StructureSection load='4j4t' size='340' side='right' caption='[[4j4t]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
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<StructureSection load='4j4t' size='340' side='right'caption='[[4j4t]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4j4t]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J4T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4j4t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J4T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1JU:1-(1,3-BENZODIOXOL-5-YLMETHYL)-5,6,7,8-TETRAHYDRO-1H-NAPHTHO[2,3-D]IMIDAZOLE'>1JU</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.34&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3uic|3uic]], [[4j1n|4j1n]], [[4j3f|4j3f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1JU:1-(1,3-BENZODIOXOL-5-YLMETHYL)-5,6,7,8-TETRAHYDRO-1H-NAPHTHO[2,3-D]IMIDAZOLE'>1JU</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4t OCA], [https://pdbe.org/4j4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j4t RCSB], [https://www.ebi.ac.uk/pdbsum/4j4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4t ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j4t OCA], [http://pdbe.org/4j4t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j4t RCSB], [http://www.ebi.ac.uk/pdbsum/4j4t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j4t ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q5NGQ3_FRATT Q5NGQ3_FRATT]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boci, T]]
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[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
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[[Category: Brubaker, L]]
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[[Category: Large Structures]]
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[[Category: Johnson, M E]]
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[[Category: Boci T]]
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[[Category: Mehboob, S]]
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[[Category: Brubaker L]]
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[[Category: Santarsiero, B D]]
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[[Category: Johnson ME]]
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[[Category: Nadh]]
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[[Category: Mehboob S]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Santarsiero BD]]
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[[Category: Reductase]]
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[[Category: Reduction]]
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[[Category: Rossmann fold]]
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Current revision

Crystal Structure of FabI from F. tularensis in complex with novel inhibitors based on the benzimidazole scaffold

PDB ID 4j4t

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