4pk7

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==crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins==
==crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins==
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<StructureSection load='4pk7' size='340' side='right' caption='[[4pk7]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
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<StructureSection load='4pk7' size='340' side='right'caption='[[4pk7]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4pk7]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PK7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4pk7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PK7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk7 OCA], [http://pdbe.org/4pk7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4pk7 RCSB], [http://www.ebi.ac.uk/pdbsum/4pk7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk7 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pk7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pk7 OCA], [https://pdbe.org/4pk7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pk7 RCSB], [https://www.ebi.ac.uk/pdbsum/4pk7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pk7 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[http://www.uniprot.org/uniprot/RAD21_HUMAN RAD21_HUMAN]] Cornelia de Lange syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:22633399</ref>
 
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/STAG2_HUMAN STAG2_HUMAN]] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.<ref>PMID:12034751</ref> [[http://www.uniprot.org/uniprot/RAD21_HUMAN RAD21_HUMAN]] Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.<ref>PMID:12417729</ref> <ref>PMID:11875078</ref>
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[https://www.uniprot.org/uniprot/STAG2_HUMAN STAG2_HUMAN] Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.<ref>PMID:12034751</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chen, Z]]
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[[Category: Homo sapiens]]
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[[Category: Hara, K]]
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[[Category: Large Structures]]
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[[Category: Tomchick, D R]]
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[[Category: Chen Z]]
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[[Category: Yu, H]]
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[[Category: Hara K]]
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[[Category: Cohesin subunit]]
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[[Category: Tomchick DR]]
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[[Category: Heat repeat]]
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[[Category: Yu H]]
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[[Category: Protein-protein interaction]]
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[[Category: Sister chromatid cohesion]]
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Current revision

crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins

PDB ID 4pk7

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