5e11

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==Second PDZ domain of Ligand of Numb protein X 2 by Laue crystallography (no electric field)==
==Second PDZ domain of Ligand of Numb protein X 2 by Laue crystallography (no electric field)==
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<StructureSection load='5e11' size='340' side='right' caption='[[5e11]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5e11' size='340' side='right'caption='[[5e11]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5e11]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5e11]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E11 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vwr|2vwr]], [[5e1y|5e1y]], [[5e21|5e21]], [[5e22|5e22]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e11 OCA], [http://pdbe.org/5e11 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e11 RCSB], [http://www.ebi.ac.uk/pdbsum/5e11 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e11 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e11 OCA], [https://pdbe.org/5e11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e11 RCSB], [https://www.ebi.ac.uk/pdbsum/5e11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e11 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/LNX2_HUMAN LNX2_HUMAN]
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The internal mechanics of proteins-the coordinated motions of amino acids and the pattern of forces constraining these motions-connects protein structure to function. Here we describe a new method combining the application of strong electric field pulses to protein crystals with time-resolved X-ray crystallography to observe conformational changes in spatial and temporal detail. Using a human PDZ domain (LNX2PDZ2) as a model system, we show that protein crystals tolerate electric field pulses strong enough to drive concerted motions on the sub-microsecond timescale. The induced motions are subtle, involve diverse physical mechanisms, and occur throughout the protein structure. The global pattern of electric-field-induced motions is consistent with both local and allosteric conformational changes naturally induced by ligand binding, including at conserved functional sites in the PDZ domain family. This work lays the foundation for comprehensive experimental study of the mechanical basis of protein function.
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Electric-field-stimulated protein mechanics.,Hekstra DR, White KI, Socolich MA, Henning RW, Srajer V, Ranganathan R Nature. 2016 Dec 15;540(7633):400-405. doi: 10.1038/nature20571. Epub 2016 Dec 7. PMID:27926732<ref>PMID:27926732</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5e11" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hekstra, D R]]
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[[Category: Homo sapiens]]
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[[Category: Henning, R W]]
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[[Category: Large Structures]]
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[[Category: Ranganathan, R]]
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[[Category: Hekstra DR]]
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[[Category: Socolich, M A]]
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[[Category: Henning RW]]
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[[Category: Srajer, V]]
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[[Category: Ranganathan R]]
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[[Category: White, K I]]
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[[Category: Socolich MA]]
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[[Category: Off state]]
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[[Category: Srajer V]]
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[[Category: Protein binding]]
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[[Category: White KI]]
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[[Category: Unperturbed]]
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Current revision

Second PDZ domain of Ligand of Numb protein X 2 by Laue crystallography (no electric field)

PDB ID 5e11

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