1rju

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[[Image:1rju.gif|left|200px]]
 
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{{Structure
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==Crystal structure of a truncated form of yeast copper thionein==
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|PDB= 1rju |SIZE=350|CAPTION= <scene name='initialview01'>1rju</scene>, resolution 1.44&Aring;
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<StructureSection load='1rju' size='340' side='right'caption='[[1rju]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene>
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<table><tr><td colspan='2'>[[1rju]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RJU FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU1:COPPER+(I)+ION'>CU1</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rju OCA], [https://pdbe.org/1rju PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rju RCSB], [https://www.ebi.ac.uk/pdbsum/1rju PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rju ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1fmy|1FMY]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rju FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rju OCA], [http://www.ebi.ac.uk/pdbsum/1rju PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rju RCSB]</span>
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__TOC__
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}}
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</StructureSection>
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[[Category: Large Structures]]
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'''Crystal structure of a truncated form of yeast copper thionein'''
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Calderone V]]
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[[Category: Del Bianco C]]
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==Overview==
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[[Category: Dolderer B]]
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We report here the crystal structure of yeast copper thionein (Cu-MT), determined at 1.44-A resolution. The Cu-MT structure shows the largest known oligonuclear Cu(I) thiolate cluster in biology, consisting of six trigonally and two digonally coordinated Cu(I) ions. This is at variance with the results from previous spectroscopic determinations, which were performed on MT samples containing seven rather than eight metal ions. The protein backbone has a random coil structure with the loops enfolding the copper cluster, which is located in a cleft where it is bound to 10 cysteine residues. The protein structure is somewhat different from that of Ag(7)-MT and similar, but not identical, to that of Cu(7)-MT. Besides the different structure of the metal cluster, the main differences lie in the cysteine topology and in the conformation of some portions of the backbone. The present structure suggests that Cu-MT, in addition to its role as a safe depository for copper ions in the cell, may play an active role in the delivery of copper to metal-free chaperones.
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[[Category: Echner H]]
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[[Category: Hartmann HJ]]
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==About this Structure==
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[[Category: Luchinat C]]
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1RJU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RJU OCA].
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[[Category: Mangani S]]
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[[Category: Weser U]]
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==Reference==
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The crystal structure of yeast copper thionein: the solution of a long-lasting enigma., Calderone V, Dolderer B, Hartmann HJ, Echner H, Luchinat C, Del Bianco C, Mangani S, Weser U, Proc Natl Acad Sci U S A. 2005 Jan 4;102(1):51-6. Epub 2004 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15613489 15613489]
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[[Category: Single protein]]
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[[Category: Bianco, C Del.]]
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[[Category: Calderone, V.]]
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[[Category: Dolderer, B.]]
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[[Category: Echner, H.]]
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[[Category: Hartmann, H J.]]
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[[Category: Luchinat, C.]]
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[[Category: Mangani, S.]]
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[[Category: Weser, U.]]
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[[Category: cu(i) metallothionein fragment]]
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[[Category: cu(i)-thiolate]]
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[[Category: yeast cu(i) metallothionein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:29:08 2008''
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Current revision

Crystal structure of a truncated form of yeast copper thionein

PDB ID 1rju

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