5uhu
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution conformation of cytochrome P450 MycG with mycinamicin IV bound== | |
| - | + | <StructureSection load='5uhu' size='340' side='right'caption='[[5uhu]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5uhu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_griseorubida Micromonospora griseorubida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UHU FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=MIV:MYCINAMICIN+IV'>MIV</scene></td></tr> |
| - | [[Category: Pochapsky | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uhu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uhu OCA], [https://pdbe.org/5uhu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uhu RCSB], [https://www.ebi.ac.uk/pdbsum/5uhu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uhu ProSAT]</span></td></tr> |
| - | [[Category: Tietz | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MYCG_MICGR MYCG_MICGR] Involved in the biosynthesis of mycinamicin, a 16-membered macrolide antibiotic. Catalyzes consecutive hydroxylation (at C14) and epoxidation (at C12-C13) reactions with mycinamicin IV as initial substrate, leading to mycinamicin II. These reactions require prior dimethylation of 6-deoxyallose to mycinose for effective conversion by the dual function MycG enzyme.<ref>PMID:18804032</ref> <ref>PMID:22547618</ref> <ref>PMID:7808395</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Micromonospora griseorubida]] | ||
| + | [[Category: Pochapsky TC]] | ||
| + | [[Category: Tietz DR]] | ||
Current revision
Solution conformation of cytochrome P450 MycG with mycinamicin IV bound
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