1rmq

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[[Image:1rmq.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of AphA class B acid phosphatase/phosphotransferase with osmiate mimicking the catalytic intermediate==
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|PDB= 1rmq |SIZE=350|CAPTION= <scene name='initialview01'>1rmq</scene>, resolution 2.00&Aring;
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<StructureSection load='1rmq' size='340' side='right'caption='[[1rmq]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>
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<table><tr><td colspan='2'>[[1rmq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RMQ FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acid_phosphatase Acid phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.2 3.1.3.2] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= APHA, NAPA, B4055, SF4149, S3580 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rmq OCA], [https://pdbe.org/1rmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rmq RCSB], [https://www.ebi.ac.uk/pdbsum/1rmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rmq ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1n8n|1N8N]], [[1n9k|1N9K]], [[1rm7|1RM7]], [[1rmt|1RMT]], [[1rmw|1RMW]], [[1rmy|1RMY]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rmq OCA], [http://www.ebi.ac.uk/pdbsum/1rmq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rmq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/APHA_ECOLI APHA_ECOLI] Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O-phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O-phospho-L-tyrosine), and to a lesser extent with 3'- and 5'-nucleotides. No activity toward ATP, phosphodiesters, glycerol-1-phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity.<ref>PMID:9011040</ref> <ref>PMID:16297670</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rm/1rmq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rmq ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of AphA class B acid phosphatase/phosphotransferase with osmiate mimicking the catalytic intermediate'''
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==See Also==
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*[[Acid phosphatase 3D structures|Acid phosphatase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1RMQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMQ OCA].
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__TOC__
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[[Category: Acid phosphatase]]
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Benvenuti, M.]]
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[[Category: Benvenuti M]]
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[[Category: Calderone, V.]]
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[[Category: Calderone V]]
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[[Category: Forleo, C.]]
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[[Category: Forleo C]]
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[[Category: Mangani, S.]]
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[[Category: Mangani S]]
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[[Category: Rossolini, G M.]]
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[[Category: Rossolini GM]]
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[[Category: Thaller, M C.]]
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[[Category: Thaller MC]]
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[[Category: class b acid phosphatase]]
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[[Category: dddd acid phosphatase]]
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[[Category: metallo-enzyme]]
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[[Category: osmiate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:30:17 2008''
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Current revision

Crystal structure of AphA class B acid phosphatase/phosphotransferase with osmiate mimicking the catalytic intermediate

PDB ID 1rmq

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