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4r43

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==Crystal Structure Analysis of MTB PEPCK==
==Crystal Structure Analysis of MTB PEPCK==
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<StructureSection load='4r43' size='340' side='right' caption='[[4r43]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4r43' size='340' side='right'caption='[[4r43]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r43]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R43 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r43]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R43 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4rcg|4rcg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoenolpyruvate_carboxykinase_(GTP) Phosphoenolpyruvate carboxykinase (GTP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.32 4.1.1.32] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r43 OCA], [https://pdbe.org/4r43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r43 RCSB], [https://www.ebi.ac.uk/pdbsum/4r43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r43 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r43 OCA], [http://pdbe.org/4r43 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r43 RCSB], [http://www.ebi.ac.uk/pdbsum/4r43 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r43 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I6Y334_MYCTU I6Y334_MYCTU]] Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.[HAMAP-Rule:MF_00452]
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[https://www.uniprot.org/uniprot/PCKG_MYCTU PCKG_MYCTU] Involved in the gluconeogenesis, in growth on fatty acids and is important for initiation of infection in the macrophages. Catalyzes the GTP-dependent conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.<ref>PMID:16691317</ref> <ref>PMID:20439709</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphoenolpyruvate carboxykinase|Phosphoenolpyruvate carboxykinase]]
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*[[Phosphoenolpyruvate carboxykinase 3D structures|Phosphoenolpyruvate carboxykinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brynda, J]]
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[[Category: Large Structures]]
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[[Category: Dostal, J]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Fanfrlik, J]]
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[[Category: Brynda J]]
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[[Category: Machova, I]]
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[[Category: Dostal J]]
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[[Category: Pichova, I]]
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[[Category: Fanfrlik J]]
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[[Category: Snasel, J]]
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[[Category: Machova I]]
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[[Category: Gdp binding]]
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[[Category: Pichova I]]
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[[Category: Kinase]]
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[[Category: Snasel J]]
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[[Category: Lyase]]
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Current revision

Crystal Structure Analysis of MTB PEPCK

PDB ID 4r43

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