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4rv7

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==Characterization of an essential diadenylate cyclase==
==Characterization of an essential diadenylate cyclase==
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<StructureSection load='4rv7' size='340' side='right' caption='[[4rv7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='4rv7' size='340' side='right'caption='[[4rv7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4rv7]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV7 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4rv7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RV7 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv7 OCA], [http://pdbe.org/4rv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rv7 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv7 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv7 OCA], [https://pdbe.org/4rv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rv7 RCSB], [https://www.ebi.ac.uk/pdbsum/4rv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rv7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DACA_LISMO DACA_LISMO]] Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes.<ref>PMID:20508090</ref>
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[https://www.uniprot.org/uniprot/DACA_LISMO DACA_LISMO] Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes.<ref>PMID:20508090</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Diadenylate cyclase]]
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[[Category: Large Structures]]
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[[Category: Dickmanns, A]]
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Ficner, R]]
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[[Category: Dickmanns A]]
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[[Category: Neumann, P]]
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[[Category: Ficner R]]
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[[Category: Atp binding]]
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[[Category: Neumann P]]
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[[Category: C-di-amp binding]]
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[[Category: Dac-fold]]
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[[Category: Transferase]]
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Current revision

Characterization of an essential diadenylate cyclase

PDB ID 4rv7

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