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4u90

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==GephE in complex with PEG crosslinked GABA receptor alpha3 subunit derived dimeric peptide==
==GephE in complex with PEG crosslinked GABA receptor alpha3 subunit derived dimeric peptide==
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<StructureSection load='4u90' size='340' side='right' caption='[[4u90]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4u90' size='340' side='right'caption='[[4u90]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4u90]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4U90 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4u90]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4U90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4U90 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3F8:1,1-[ETHANE-1,2-DIYLBIS(OXYETHANE-2,1-DIYL)]BIS(1H-PYRROLE-2,5-DIONE)'>3F8</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4u91|4u91]], [[4pd0|4pd0]], [[4pd1|4pd1]], [[4tk1|4tk1]], [[4tk2|4tk2]], [[4tk3|4tk3]], [[4tk4|4tk4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3F8:1,1-[ETHANE-1,2-DIYLBIS(OXYETHANE-2,1-DIYL)]BIS(1H-PYRROLE-2,5-DIONE)'>3F8</scene>, <scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u90 OCA], [http://pdbe.org/4u90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4u90 RCSB], [http://www.ebi.ac.uk/pdbsum/4u90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4u90 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4u90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u90 OCA], [https://pdbe.org/4u90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4u90 RCSB], [https://www.ebi.ac.uk/pdbsum/4u90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4u90 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT]] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref> [[http://www.uniprot.org/uniprot/GBRA3_RAT GBRA3_RAT]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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[https://www.uniprot.org/uniprot/GEPH_RAT GEPH_RAT] Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.<ref>PMID:8264797</ref> <ref>PMID:9990024</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4u90" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4u90" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gephyrin|Gephyrin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Kasaragod, V B]]
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[[Category: Large Structures]]
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[[Category: Maric, H M]]
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[[Category: Rattus norvegicus]]
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[[Category: Schindelin, H]]
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[[Category: Kasaragod VB]]
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[[Category: Gaba type a receptor]]
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[[Category: Maric HM]]
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[[Category: Inhibitory synapse]]
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[[Category: Schindelin H]]
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[[Category: Scaffolding protein]]
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[[Category: Transfer protein - structural protein complex]]
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[[Category: Transferase]]
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Current revision

GephE in complex with PEG crosslinked GABA receptor alpha3 subunit derived dimeric peptide

PDB ID 4u90

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