4w9m

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==AMPPNP bound Rad50 in complex with dsDNA==
==AMPPNP bound Rad50 in complex with dsDNA==
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<StructureSection load='4w9m' size='340' side='right' caption='[[4w9m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4w9m' size='340' side='right'caption='[[4w9m]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4w9m]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4W9M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4w9m]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4W9M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4W9M FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4w9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9m OCA], [http://pdbe.org/4w9m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4w9m RCSB], [http://www.ebi.ac.uk/pdbsum/4w9m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9m ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4w9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4w9m OCA], [https://pdbe.org/4w9m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4w9m RCSB], [https://www.ebi.ac.uk/pdbsum/4w9m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4w9m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAD50_THEMA RAD50_THEMA]] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
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[https://www.uniprot.org/uniprot/RAD50_THEMA RAD50_THEMA] Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lammens, K]]
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[[Category: Large Structures]]
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[[Category: Rojowska, A]]
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[[Category: Synthetic construct]]
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[[Category: Atpase]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: Dna amppnp bound]]
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[[Category: Lammens K]]
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[[Category: Hydrolase]]
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[[Category: Rojowska A]]

Current revision

AMPPNP bound Rad50 in complex with dsDNA

PDB ID 4w9m

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