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1rtq

From Proteopedia

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[[Image:1rtq.gif|left|200px]]
 
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{{Structure
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==The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica==
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|PDB= 1rtq |SIZE=350|CAPTION= <scene name='initialview01'>1rtq</scene>, resolution 0.95&Aring;
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<StructureSection load='1rtq' size='340' side='right'caption='[[1rtq]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1rtq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_proteolyticus Vibrio proteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RTQ FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bacterial_leucyl_aminopeptidase Bacterial leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.10 3.4.11.10] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtq OCA], [https://pdbe.org/1rtq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rtq RCSB], [https://www.ebi.ac.uk/pdbsum/1rtq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rtq ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1amp|1AMP]], [[1cp6|1CP6]], [[1ft7|1FT7]], [[1lok|1LOK]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtq OCA], [http://www.ebi.ac.uk/pdbsum/1rtq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/AMPX_VIBPR AMPX_VIBPR]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rt/1rtq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rtq ConSurf].
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<div style="clear:both"></div>
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'''The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica'''
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==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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==Overview==
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__TOC__
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The aminopeptidase from Aeromonas proteolytica (AAP) contains two zinc ions in the active site and catalyzes the degradation of peptides. Herein we report the crystal structures of AAP at 0.95-A resolution at neutral pH and at 1.24-A resolution at low pH. The combination of these structures allowed the precise modeling of atomic positions, the identification of the metal bridging oxygen species, and insight into the physical properties of the metal ions. On the basis of these structures, a new putative catalytic mechanism is proposed for AAP that is likely relevant to all binuclear metalloproteases.
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</StructureSection>
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[[Category: Large Structures]]
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==About this Structure==
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1RTQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_proteolyticus Vibrio proteolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RTQ OCA].
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==Reference==
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The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica., Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC, J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16596389 16596389]
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[[Category: Bacterial leucyl aminopeptidase]]
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[[Category: Single protein]]
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[[Category: Vibrio proteolyticus]]
[[Category: Vibrio proteolyticus]]
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[[Category: Bienvenue, D L.]]
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[[Category: Bienvenue DL]]
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[[Category: Desmarais, W.]]
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[[Category: Desmarais W]]
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[[Category: Holz, R C.]]
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[[Category: Holz RC]]
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[[Category: Krzysztof, B P.]]
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[[Category: Krzysztof BP]]
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[[Category: Petsko, G A.]]
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[[Category: Petsko GA]]
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[[Category: Ringe, D.]]
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[[Category: Ringe D]]
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[[Category: aminopeptidase]]
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[[Category: bimetallic]]
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[[Category: high resolution]]
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[[Category: zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:48 2008''
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Current revision

The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica

PDB ID 1rtq

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