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5m0j

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==Crystal structure of the cytoplasmic complex with She2p, She3p, and the ASH1 mRNA E3-localization element==
==Crystal structure of the cytoplasmic complex with She2p, She3p, and the ASH1 mRNA E3-localization element==
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<StructureSection load='5m0j' size='340' side='right' caption='[[5m0j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5m0j' size='340' side='right'caption='[[5m0j]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5m0j]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M0J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M0J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5m0j]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_RM11-1a Saccharomyces cerevisiae RM11-1a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M0J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5m0h|5m0h]], [[5m0i|5m0i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m0j OCA], [http://pdbe.org/5m0j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m0j RCSB], [http://www.ebi.ac.uk/pdbsum/5m0j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m0j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m0j OCA], [https://pdbe.org/5m0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m0j RCSB], [https://www.ebi.ac.uk/pdbsum/5m0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m0j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SHE2_YEAS1 SHE2_YEAS1]] RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Recruits also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA (By similarity).
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[https://www.uniprot.org/uniprot/SHE3_YEAST SHE3_YEAST] RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud.<ref>PMID:9809065</ref> <ref>PMID:10359695</ref> <ref>PMID:10212145</ref> <ref>PMID:11032818</ref> <ref>PMID:11101531</ref> <ref>PMID:12499354</ref> <ref>PMID:14691136</ref> <ref>PMID:14561888</ref> <ref>PMID:15328357</ref> <ref>PMID:16890529</ref> <ref>PMID:19429778</ref> [https://www.uniprot.org/uniprot/SHE2_YEAST SHE2_YEAST] RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Recruits the MYO4-SHE3 complex to the ASH1 mRNA. Recruites also LOC1 and PUF6 to ASH1 mRNA, which are required for translational repression of this mRNA.<ref>PMID:10212145</ref> <ref>PMID:10359695</ref> <ref>PMID:11032818</ref> <ref>PMID:11101531</ref> <ref>PMID:12499354</ref> <ref>PMID:13679573</ref> <ref>PMID:14561888</ref> <ref>PMID:14691136</ref> <ref>PMID:15328357</ref> <ref>PMID:15537539</ref> <ref>PMID:15899876</ref> <ref>PMID:16890529</ref> <ref>PMID:18566598</ref> <ref>PMID:19244342</ref> <ref>PMID:20713510</ref> <ref>PMID:9809065</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Edelmann, F T]]
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[[Category: Large Structures]]
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[[Category: Janowski, R]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Niessing, D]]
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[[Category: Saccharomyces cerevisiae RM11-1a]]
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[[Category: Ash1-mrna]]
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[[Category: Edelmann FT]]
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[[Category: Mrna transport]]
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[[Category: Janowski R]]
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[[Category: Rna binding protein]]
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[[Category: Niessing D]]
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[[Category: She2p]]
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[[Category: She3p]]
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Current revision

Crystal structure of the cytoplasmic complex with She2p, She3p, and the ASH1 mRNA E3-localization element

PDB ID 5m0j

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