5mvb
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.== | |
| + | <StructureSection load='5mvb' size='340' side='right'caption='[[5mvb]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5mvb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MVB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MVB FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AUZ:bis(m2-Oxo)-bis(2-methyl-2,2-bipyridine)-di-gold(iii)'>AUZ</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mvb OCA], [https://pdbe.org/5mvb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mvb RCSB], [https://www.ebi.ac.uk/pdbsum/5mvb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mvb ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Telomeric G-quadruplexes have recently emerged as drug targets in cancer research. Herein, we present the first NMR structure of a telomeric DNA G-quadruplex that adopts the biologically relevant hybrid-2 conformation in a ligand-bound state. We solved the complex with a metalorganic gold(III) ligand that stabilizes G-quadruplexes. Analysis of the free and bound structures reveals structural changes in the capping region of the G-quadruplex. The ligand is sandwiched between one terminal G-tetrad and a flanking nucleotide. This complex structure involves a major structural rearrangement compared to the free G-quadruplex structure as observed for other G-quadruplexes in different conformations, invalidating simple docking approaches to ligand-G-quadruplex structure determination. | ||
| - | + | Solution NMR Structure of a Ligand/Hybrid-2-G-Quadruplex Complex Reveals Rearrangements that Affect Ligand Binding.,Wirmer-Bartoschek J, Bendel LE, Jonker HRA, Grun JT, Papi F, Bazzicalupi C, Messori L, Gratteri P, Schwalbe H Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7102-7106. doi:, 10.1002/anie.201702135. Epub 2017 May 19. PMID:28524432<ref>PMID:28524432</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5mvb" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Gratteri | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Jonker | + | [[Category: Homo sapiens]] |
| - | [[Category: Schwalbe | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Bazzicalupi C]] |
| + | [[Category: Bendel LE]] | ||
| + | [[Category: Gratteri P]] | ||
| + | [[Category: Gruen T]] | ||
| + | [[Category: Jonker HRA]] | ||
| + | [[Category: Messori L]] | ||
| + | [[Category: Schwalbe H]] | ||
| + | [[Category: Wirmer-Bartoschek J]] | ||
Current revision
Solution structure of a human G-Quadruplex hybrid-2 form in complex with a Gold-ligand.
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