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| - | [[Image:1rxa.gif|left|200px]] | |
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| - | {{Structure
| + | ==CRYSTAL STRUCTURE OF R(CCCCGGGG) IN TWO DISTINCT LATTICES== |
| - | |PDB= 1rxa |SIZE=350|CAPTION= <scene name='initialview01'>1rxa</scene>, resolution 2.900Å
| + | <StructureSection load='1rxa' size='340' side='right'caption='[[1rxa]], [[Resolution|resolution]] 2.90Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>
| + | <table><tr><td colspan='2'>[[1rxa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RXA FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxa OCA], [https://pdbe.org/1rxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rxa RCSB], [https://www.ebi.ac.uk/pdbsum/1rxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rxa ProSAT]</span></td></tr> |
| - | |DOMAIN=
| + | </table> |
| - | |RELATEDENTRY=
| + | __TOC__ |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rxa OCA], [http://www.ebi.ac.uk/pdbsum/1rxa PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rxa RCSB]</span>
| + | </StructureSection> |
| - | }}
| + | [[Category: Large Structures]] |
| - | | + | [[Category: Egli M]] |
| - | '''CRYSTAL STRUCTURE OF R(CCCCGGGG) IN TWO DISTINCT LATTICES'''
| + | [[Category: Portmann S]] |
| - | | + | [[Category: Usman N]] |
| - | | + | |
| - | ==Overview==
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| - | The structure of the RNA octamer r(C4G4) has been determined in two different crystal forms. The conformations of the RNA duplex in the rhombohedral and hexagonal lattices display only minimal deviations, demonstrating that the RNA double helix is considerably less deformable than the DNA double helix. For the first time the crystal structures of an A-RNA and an A-DNA with identical sequence can now be compared. The large number of ordered water molecules observed in the minor groove of the RNA duplex suggests that an important contribution to its higher rigidity derives from the improved hydration due to the presence of the 2'-hydroxyl groups. Our finding that the conformation of the RNA double helix is virtually unaffected by different crystal packing modes provides evidence that proteins may not alter the conformation of RNA stem regions in a significant way.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1RXA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXA OCA].
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| - | ==Reference==
| + | |
| - | The crystal structure of r(CCCCGGGG) in two distinct lattices., Portmann S, Usman N, Egli M, Biochemistry. 1995 Jun 13;34(23):7569-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7779802 7779802]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Egli, M.]] | + | |
| - | [[Category: Portmann, S.]] | + | |
| - | [[Category: Usman, N.]] | + | |
| - | [[Category: a-rna]]
| + | |
| - | [[Category: double helix]]
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:15 2008''
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