1ryj

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[[Image:1ryj.gif|left|200px]]
 
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{{Structure
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==Solution NMR Structure of Protein Mth1743 from Methanobacterium thermoautotrophicum. Ontario Centre for Structural Proteomics target MTH1743_1_70; Northeast Structural Genomics Consortium Target TT526.==
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|PDB= 1ryj |SIZE=350|CAPTION= <scene name='initialview01'>1ryj</scene>
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<StructureSection load='1ryj' size='340' side='right'caption='[[1ryj]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1ryj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1jsb 1jsb]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RYJ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= archaea ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2186 Methanothermococcus thermolithotrophicus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ryj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ryj OCA], [https://pdbe.org/1ryj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ryj RCSB], [https://www.ebi.ac.uk/pdbsum/1ryj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ryj ProSAT], [https://www.topsan.org/Proteins/NESGC/1ryj TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ryj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ryj OCA], [http://www.ebi.ac.uk/pdbsum/1ryj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ryj RCSB]</span>
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[https://www.uniprot.org/uniprot/O27775_METTH O27775_METTH]
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}}
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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'''Solution NMR Structure of Protein Mth1743 from Methanobacterium thermoautotrophicum. Ontario Centre for Structural Proteomics target MTH1743_1_70; Northeast Structural Genomics Consortium Target TT526.'''
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==Overview==
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The influx of genomic sequence information has led to the concept of structural proteomics, the determination of protein structures on a genome-wide scale. Here we describe an approach to structural proteomics of small proteins using NMR spectroscopy. Over 500 small proteins from several organisms were cloned, expressed, purified, and evaluated by NMR. Although there was variability among proteomes, overall 20% of these proteins were found to be readily amenable to NMR structure determination. NMR sample preparation was centralized in one facility, and a distributive approach was used for NMR data collection and analysis. Twelve structures are reported here as part of this approach, which allowed us to infer putative functions for several conserved hypothetical proteins.
The influx of genomic sequence information has led to the concept of structural proteomics, the determination of protein structures on a genome-wide scale. Here we describe an approach to structural proteomics of small proteins using NMR spectroscopy. Over 500 small proteins from several organisms were cloned, expressed, purified, and evaluated by NMR. Although there was variability among proteomes, overall 20% of these proteins were found to be readily amenable to NMR structure determination. NMR sample preparation was centralized in one facility, and a distributive approach was used for NMR data collection and analysis. Twelve structures are reported here as part of this approach, which allowed us to infer putative functions for several conserved hypothetical proteins.
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==About this Structure==
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An NMR approach to structural proteomics.,Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1825-30. PMID:11854485<ref>PMID:11854485</ref>
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1RYJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermococcus_thermolithotrophicus Methanothermococcus thermolithotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RYJ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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An NMR approach to structural proteomics., Yee A, Chang X, Pineda-Lucena A, Wu B, Semesi A, Le B, Ramelot T, Lee GM, Bhattacharyya S, Gutierrez P, Denisov A, Lee CH, Cort JR, Kozlov G, Liao J, Finak G, Chen L, Wishart D, Lee W, McIntosh LP, Gehring K, Kennedy MA, Edwards AM, Arrowsmith CH, Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):1825-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11854485 11854485]
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</div>
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<div class="pdbe-citations 1ryj" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Methanothermococcus thermolithotrophicus]]
[[Category: Methanothermococcus thermolithotrophicus]]
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[[Category: Single protein]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bhattacharyya S]]
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[[Category: Bhattacharyya, S.]]
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[[Category: Chang X]]
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[[Category: Chang, X.]]
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[[Category: Chen L]]
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[[Category: Chen, L.]]
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[[Category: Cort JR]]
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[[Category: Cort, J R.]]
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[[Category: Denisov A]]
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[[Category: Denisov, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Finak G]]
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[[Category: Finak, G.]]
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[[Category: Gehring K]]
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[[Category: Gehring, K.]]
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[[Category: Gutierrez P]]
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[[Category: Gutierrez, P.]]
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[[Category: Kennedy MA]]
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[[Category: Kennedy, M A.]]
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[[Category: Kozlov G]]
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[[Category: Kozlov, G.]]
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[[Category: Le B]]
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[[Category: Le, B.]]
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[[Category: Lee CH]]
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[[Category: Lee, C H.]]
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[[Category: Lee GM]]
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[[Category: Lee, G M.]]
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[[Category: Lee W]]
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[[Category: Lee, W.]]
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[[Category: Liao J]]
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[[Category: Liao, J.]]
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[[Category: McIntosh LP]]
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[[Category: McIntosh, L P.]]
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[[Category: Pineda-Lucena A]]
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[[Category: NESG, Northeast Structural Genomics Consortium.]]
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[[Category: Ramelot T]]
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[[Category: Pineda-Lucena, A.]]
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[[Category: Semesi A]]
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[[Category: Ramelot, T.]]
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[[Category: Wishart D]]
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[[Category: Semesi, A.]]
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[[Category: Wu B]]
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[[Category: Wishart, D.]]
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[[Category: Yee A]]
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[[Category: Wu, B.]]
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[[Category: Yee, A.]]
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[[Category: beta/alpha protein]]
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[[Category: nesg]]
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[[Category: northeast structural genomics consortium]]
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[[Category: ocsp]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:34:47 2008''
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Current revision

Solution NMR Structure of Protein Mth1743 from Methanobacterium thermoautotrophicum. Ontario Centre for Structural Proteomics target MTH1743_1_70; Northeast Structural Genomics Consortium Target TT526.

PDB ID 1ryj

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