5h12

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==Crystal structure of Deep Vent DNA Polymerase==
==Crystal structure of Deep Vent DNA Polymerase==
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<StructureSection load='5h12' size='340' side='right' caption='[[5h12]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5h12' size='340' side='right'caption='[[5h12]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5h12]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H12 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5h12]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus Pyrococcus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H12 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h12 OCA], [http://pdbe.org/5h12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h12 RCSB], [http://www.ebi.ac.uk/pdbsum/5h12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h12 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h12 OCA], [https://pdbe.org/5h12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h12 RCSB], [https://www.ebi.ac.uk/pdbsum/5h12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h12 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOL_PYRSD DPOL_PYRSD] In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' exonuclease activity.[UniProtKB:P77933] Intein encoded endonucleases are thought to mediate intein mobility by site-specific recombination initiated by endonuclease cleavage at the 'homing site' in gene that lack the intein (Probable). Intein splicing has been shown to occur via a branched intermediate that is resolved as the reaction proceeds; formation of the branched intermediate is reversible in response to pH shifts (PubMed:8269515).<ref>PMID:8269515</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hikida, Y]]
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[[Category: Large Structures]]
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[[Category: Hirao, I]]
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[[Category: Pyrococcus]]
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[[Category: Kimoto, M]]
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[[Category: Hikida Y]]
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[[Category: Yokoyama, S]]
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[[Category: Hirao I]]
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[[Category: Dna polymerase]]
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[[Category: Kimoto M]]
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[[Category: Transferase]]
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[[Category: Yokoyama S]]

Current revision

Crystal structure of Deep Vent DNA Polymerase

PDB ID 5h12

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