1rz2

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[[Image:1rz2.jpg|left|200px]]
 
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{{Structure
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==1.6A crystal structure of the protein BA4783/Q81L49 (similar to sortase B) from Bacillus anthracis.==
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|PDB= 1rz2 |SIZE=350|CAPTION= <scene name='initialview01'>1rz2</scene>, resolution 1.60&Aring;
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<StructureSection load='1rz2' size='340' side='right'caption='[[1rz2]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1rz2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._Ames Bacillus anthracis str. Ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1RZ2 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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|GENE= BA4783 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=198094 Bacillus anthracis str. Ames])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1rz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz2 OCA], [https://pdbe.org/1rz2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1rz2 RCSB], [https://www.ebi.ac.uk/pdbsum/1rz2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1rz2 ProSAT], [https://www.topsan.org/Proteins/MCSG/1rz2 TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG4509 COG4509]</span>
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</table>
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|RELATEDENTRY=[[1ng5|1NG5]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rz2 OCA], [http://www.ebi.ac.uk/pdbsum/1rz2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rz2 RCSB]</span>
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[https://www.uniprot.org/uniprot/A0A6L8PZR0_BACAN A0A6L8PZR0_BACAN]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''1.6A crystal structure of the protein BA4783/Q81L49 (similar to sortase B) from Bacillus anthracis.'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rz/1rz2_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Surface proteins attached by sortases to the cell wall envelope of bacterial pathogens play important roles during infection. Sorting and attachment of these proteins is directed by C-terminal signals. Sortase B of S. aureus recognizes a motif NPQTN, cleaves the polypeptide after the Thr residue, and attaches the protein to pentaglycine cross-bridges. Sortase B of B. anthracis is thought to recognize the NPKTG motif, and attaches surface proteins to m-diaminopimelic acid cross-bridges. We have determined crystal structure of sortase B from B. anthracis and S. aureus at 1.6 and 2.0 A resolutions, respectively. These structures show a beta-barrel fold with alpha-helical elements on its outside, a structure thus far exclusive to the sortase family. A putative active site located on the edge of the beta-barrel is comprised of a Cys-His-Asp catalytic triad and presumably faces the bacterial cell surface. A putative binding site for the sorting signal is located nearby.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1rz2 ConSurf].
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1RZ2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_anthracis_str._ames Bacillus anthracis str. ames]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RZ2 OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Structures of sortase B from Staphylococcus aureus and Bacillus anthracis reveal catalytic amino acid triad in the active site., Zhang R, Wu R, Joachimiak G, Mazmanian SK, Missiakas DM, Gornicki P, Schneewind O, Joachimiak A, Structure. 2004 Jul;12(7):1147-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15242591 15242591]
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[[Category: Bacillus anthracis str. Ames]]
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[[Category: Bacillus anthracis str. ames]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Gornicki P]]
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[[Category: Gornicki, P.]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A.]]
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[[Category: Wu R]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: Zhang R]]
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[[Category: Wu, R.]]
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[[Category: Zhang, R.]]
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[[Category: b. anthracis]]
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[[Category: mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: sortase b protein]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:35:04 2008''
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Current revision

1.6A crystal structure of the protein BA4783/Q81L49 (similar to sortase B) from Bacillus anthracis.

PDB ID 1rz2

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OCA

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