5hnu

<StructureSection load='5hnu' size='340' side='right' caption='[[5hnu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[5hnu]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HNU FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=65D:OCTYL+3,4,5-TRIHYDROXYBENZOATE'>65D</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hnt|5hnt]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hnu OCA], [http://pdbe.org/5hnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hnu RCSB], [http://www.ebi.ac.uk/pdbsum/5hnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hnu ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN]] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

[[Category: Hu, X]]

[[Category: Li, C]]

[[Category: Zhang, H]]

[[Category: Zhao, Y]]

[[Category: Akr1c3]]

[[Category: Inhibition]]

[[Category: Oxidoreductase]]