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4x91

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==Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)==
==Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)==
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<StructureSection load='4x91' size='340' side='right' caption='[[4x91]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4x91' size='340' side='right'caption='[[4x91]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x91]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X91 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x91]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X91 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X91 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=IEF:PROPAN-2-YL+(R)-TRIDEC-12-EN-1-YLPHOSPHONOFLUORIDATE'>IEF</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x90|4x90]], [[4x92|4x92]], [[4x93|4x93]], [[4x94|4x94]], [[4x95|4x95]], [[4x96|4x96]], [[4x97|4x97]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TO4:propan-2-yl+(R)-dodec-11-en-1-ylphosphonofluoridate'>TO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x91 OCA], [http://pdbe.org/4x91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4x91 RCSB], [http://www.ebi.ac.uk/pdbsum/4x91 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4x91 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x91 OCA], [https://pdbe.org/4x91 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x91 RCSB], [https://www.ebi.ac.uk/pdbsum/4x91 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x91 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN]] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
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[https://www.uniprot.org/uniprot/PAG15_HUMAN PAG15_HUMAN] Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phospholipase A2|Phospholipase A2]]
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*[[Phospholipase A2 3D structures|Phospholipase A2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Glukhova, A]]
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[[Category: Homo sapiens]]
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[[Category: Tesmer, J J.G]]
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[[Category: Large Structures]]
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[[Category: Acyltransferase]]
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[[Category: Glukhova A]]
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[[Category: Hydrolase]]
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[[Category: Tesmer JJG]]
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[[Category: Idfp]]
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[[Category: Phospholipase]]
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[[Category: Transferase]]
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Current revision

Crystal structure of Lysosomal Phospholipase A2 in complex with Isopropyl dodec-11-enylfluorophosphonate (IDFP)

PDB ID 4x91

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