4wja
From Proteopedia
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==Crystal Structure of PAXX== | ==Crystal Structure of PAXX== | ||
- | <StructureSection load='4wja' size='340' side='right' caption='[[4wja]], [[Resolution|resolution]] 2.60Å' scene=''> | + | <StructureSection load='4wja' size='340' side='right'caption='[[4wja]], [[Resolution|resolution]] 2.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[4wja]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJA OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4wja]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WJA FirstGlance]. <br> |
- | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wja OCA], [https://pdbe.org/4wja PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wja RCSB], [https://www.ebi.ac.uk/pdbsum/4wja PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wja ProSAT]</span></td></tr> | ||
</table> | </table> | ||
- | + | == Function == | |
- | = | + | [https://www.uniprot.org/uniprot/PAXX_HUMAN PAXX_HUMAN] Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:25574025, PubMed:25670504, PubMed:25941166, PubMed:27705800). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:25574025, PubMed:25670504, PubMed:25941166). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (PubMed:27703001). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (PubMed:30250067, PubMed:25670504). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27705800). Able to restrict infection by herpesvirus 1 (HSV-1) via an unknown mechanism (PubMed:29144403).<ref>PMID:25574025</ref> <ref>PMID:25670504</ref> <ref>PMID:25941166</ref> <ref>PMID:27703001</ref> <ref>PMID:27705800</ref> <ref>PMID:29144403</ref> <ref>PMID:30250067</ref> |
- | Non-homologous end joining (NHEJ) | + | |
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- | </ | + | |
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== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: Dong | + | [[Category: Homo sapiens]] |
- | [[Category: Feng | + | [[Category: Large Structures]] |
- | [[Category: Gao | + | [[Category: Dong C]] |
- | [[Category: Guo | + | [[Category: Feng F]] |
- | [[Category: Hou | + | [[Category: Gao G]] |
- | [[Category: Huo | + | [[Category: Guo R]] |
- | [[Category: Ji | + | [[Category: Hou M]] |
- | [[Category: Lan | + | [[Category: Huo W]] |
- | [[Category: Li | + | [[Category: Ji J]] |
- | [[Category: Liang | + | [[Category: Lan L]] |
- | [[Category: Ning | + | [[Category: Li W]] |
- | [[Category: Wang | + | [[Category: Liang H]] |
- | [[Category: Wei | + | [[Category: Ning S]] |
- | [[Category: Xing | + | [[Category: Wang Q]] |
- | [[Category: Xu | + | [[Category: Wei L]] |
- | [[Category: Yan | + | [[Category: Xing M]] |
- | [[Category: Yang | + | [[Category: Xu D]] |
- | + | [[Category: Yan Z]] | |
- | + | [[Category: Yang M]] | |
- | + |
Current revision
Crystal Structure of PAXX
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