4xdk

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==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine==
==Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine==
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<StructureSection load='4xdk' size='340' side='right' caption='[[4xdk]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='4xdk' size='340' side='right'caption='[[4xdk]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4xdk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4xdk]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XDK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=405:(3S)-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>405</scene>, <scene name='pdbligand=408:(3R)-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>408</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4bw5|4bw5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=405:(3S)-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>405</scene>, <scene name='pdbligand=408:(3R)-3-PHENYL-3-[4-(TRIFLUOROMETHYL)PHENOXY]PROPAN-1-AMINE'>408</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdk OCA], [http://pdbe.org/4xdk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdk RCSB], [http://www.ebi.ac.uk/pdbsum/4xdk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xdk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdk OCA], [https://pdbe.org/4xdk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xdk RCSB], [https://www.ebi.ac.uk/pdbsum/4xdk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xdk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN]] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
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[https://www.uniprot.org/uniprot/KCNKA_HUMAN KCNKA_HUMAN] Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Potassium Channel|Potassium Channel]]
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: ARROWSMITH, C H]]
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[[Category: Homo sapiens]]
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[[Category: BOUNTRA, C]]
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[[Category: Large Structures]]
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[[Category: BURGESS-BROWN, N A]]
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[[Category: Arrowsmith CH]]
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[[Category: CARPENTER, E P]]
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[[Category: Bountra C]]
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[[Category: DONG, Y Y]]
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[[Category: Burgess-Brown NA]]
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[[Category: EDWARDS, A M]]
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[[Category: Carpenter EP]]
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[[Category: MACKENZIE, A]]
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[[Category: Dong YY]]
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[[Category: MUKHOPADHYAY, S]]
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[[Category: Edwards AM]]
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[[Category: PIKE, A C.W]]
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[[Category: Mackenzie A]]
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[[Category: Structural genomic]]
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[[Category: Mukhopadhyay S]]
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[[Category: K2p]]
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[[Category: Pike ACW]]
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[[Category: Membrane protein]]
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[[Category: Outward rectification]]
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[[Category: Sgc]]
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[[Category: Transport protein]]
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Current revision

Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine

PDB ID 4xdk

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