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4wjl

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==Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels==
==Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels==
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<StructureSection load='4wjl' size='340' side='right' caption='[[4wjl]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='4wjl' size='340' side='right'caption='[[4wjl]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wjl]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WJL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wjl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WJL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wjl OCA], [http://pdbe.org/4wjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wjl RCSB], [http://www.ebi.ac.uk/pdbsum/4wjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wjl ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wjl OCA], [https://pdbe.org/4wjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wjl RCSB], [https://www.ebi.ac.uk/pdbsum/4wjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wjl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/DPP10_HUMAN DPP10_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/DPP10_HUMAN DPP10_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DPP10_HUMAN DPP10_HUMAN]] Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).<ref>PMID:12662155</ref> <ref>PMID:15454437</ref> <ref>PMID:15671030</ref>
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[https://www.uniprot.org/uniprot/DPP10_HUMAN DPP10_HUMAN] Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:15454437). Has no dipeptidyl aminopeptidase activity (PubMed:12662155).<ref>PMID:12662155</ref> <ref>PMID:15454437</ref> <ref>PMID:15671030</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Dipeptidyl peptidase|Dipeptidyl peptidase]]
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*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bezerra, G A]]
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[[Category: Homo sapiens]]
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[[Category: Dhe-Paganon, S]]
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[[Category: Large Structures]]
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[[Category: Dobrovetsky, E]]
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[[Category: Bezerra GA]]
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[[Category: Fedosyuk, S]]
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[[Category: Dhe-Paganon S]]
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[[Category: Gruber, K]]
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[[Category: Dobrovetsky E]]
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[[Category: Seitova, A]]
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[[Category: Fedosyuk S]]
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[[Category: Alpha/beta hydrolase]]
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[[Category: Gruber K]]
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[[Category: Beta-propeller]]
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[[Category: Seitova A]]
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[[Category: Dpp4 structure homologue]]
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[[Category: Inactive dipeptidyl peptidase 10]]
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[[Category: Membrane protein]]
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Current revision

Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels

PDB ID 4wjl

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