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4wpn

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==Structure of human ALDH1A1 with inhibitor CM053==
==Structure of human ALDH1A1 with inhibitor CM053==
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<StructureSection load='4wpn' size='340' side='right' caption='[[4wpn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4wpn' size='340' side='right'caption='[[4wpn]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wpn]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WPN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WPN FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3ST:1-{[1,3-DIMETHYL-7-(3-METHYLBUTYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PIPERIDINE-4-CARBOXAMIDE'>3ST</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Retinal_dehydrogenase Retinal dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.36 1.2.1.36] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ST:1-{[1,3-DIMETHYL-7-(3-METHYLBUTYL)-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YL]METHYL}PIPERIDINE-4-CARBOXAMIDE'>3ST</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=YB:YTTERBIUM+(III)+ION'>YB</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpn OCA], [http://pdbe.org/4wpn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wpn RCSB], [http://www.ebi.ac.uk/pdbsum/4wpn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpn ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wpn OCA], [https://pdbe.org/4wpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wpn RCSB], [https://www.ebi.ac.uk/pdbsum/4wpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wpn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN]] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
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[https://www.uniprot.org/uniprot/AL1A1_HUMAN AL1A1_HUMAN] Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4wpn" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4wpn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Retinal dehydrogenase]]
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[[Category: Homo sapiens]]
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[[Category: Hurley, T D]]
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[[Category: Large Structures]]
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[[Category: Morgan, C A]]
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[[Category: Hurley TD]]
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[[Category: Oxidoreductase enzyme inhibitor]]
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[[Category: Morgan CA]]

Current revision

Structure of human ALDH1A1 with inhibitor CM053

PDB ID 4wpn

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