1s1j

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[[Image:1s1j.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1==
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|PDB= 1s1j |SIZE=350|CAPTION= <scene name='initialview01'>1s1j</scene>, resolution 2.18&Aring;
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<StructureSection load='1s1j' size='340' side='right'caption='[[1s1j]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=IQZ:(7AS,12AR,12BS)-1,2,3,4,7A,12,12A,12B-OCTAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene>
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<table><tr><td colspan='2'>[[1s1j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1J FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
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|GENE= ZIPA, B2412 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IQZ:(12BS)-1,2,3,4,12,12B-HEXAHYDROINDOLO[2,3-A]QUINOLIZIN-7(6H)-ONE'>IQZ</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1j OCA], [https://pdbe.org/1s1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1j RCSB], [https://www.ebi.ac.uk/pdbsum/1s1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1j ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1s1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1j OCA], [http://www.ebi.ac.uk/pdbsum/1s1j PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1s1j RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ZIPA_ECOLI ZIPA_ECOLI] Interacts directly with the cell division protein FtsZ. Probable receptor for the septal ring structure, may anchor it to the inner-membrane.[HAMAP-Rule:MF_00509]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/s1/1s1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1s1j ConSurf].
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<div style="clear:both"></div>
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'''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''
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==See Also==
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*[[Cell division protein 3D structures|Cell division protein 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
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==About this Structure==
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1S1J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA].
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==Reference==
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Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15006376 15006376]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Ding, W.]]
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[[Category: Ding W]]
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[[Category: Dushin, E G.]]
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[[Category: Dushin EG]]
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[[Category: Foreman, K W.]]
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[[Category: Foreman KW]]
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[[Category: III, T S.Rush.]]
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[[Category: Jenning LD]]
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[[Category: Jenning, L D.]]
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[[Category: Kenney CH]]
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[[Category: Kenney, C H.]]
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[[Category: Li Y]]
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[[Category: Li, Y.]]
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[[Category: Moghazeh SL]]
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[[Category: Moghazeh, S L.]]
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[[Category: Mosyak L]]
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[[Category: Mosyak, L.]]
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[[Category: Peterson PJ]]
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[[Category: Peterson, P J.]]
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[[Category: Rush III TS]]
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[[Category: Ruzin, A V.]]
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[[Category: Ruzin AV]]
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[[Category: Sukhdeo, M N.]]
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[[Category: Sukhdeo MN]]
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[[Category: Sutherland, A G.]]
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[[Category: Sutherland AG]]
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[[Category: Tsao, D H.]]
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[[Category: Tsao DH]]
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[[Category: Tuckman, M.]]
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[[Category: Tuckman M]]
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[[Category: cell cycle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:36:02 2008''
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Current revision

Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1

PDB ID 1s1j

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