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Contactin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='5i99' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Contactin''' (CNTN) is a neuronal cell surface glycoprotein which a...) |
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| - | + | <StructureSection load='5i99' size='340' side='right' caption='Mouse contactin-3 domains Ig1-Ig4 complex with glycerol (PDB code [[5i99]])' scene=''> | |
| - | <StructureSection load='5i99' size='340' side='right' caption=' | + | |
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
contactin-4 is an autism susceptibility locus<ref>PMID:21308999</ref>. | contactin-4 is an autism susceptibility locus<ref>PMID:21308999</ref>. | ||
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| - | == Relevance == | ||
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| - | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
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* Contactin-1 | * Contactin-1 | ||
| - | + | **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human <br /> | |
| - | **[[3s97]] – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | + | |
**[[2ee2]] – hCNTN FN3 domains - NMR <br /> | **[[2ee2]] – hCNTN FN3 domains - NMR <br /> | ||
| + | **[[5e53]] – cCNTN FN1-FN3 domains – chicken <br /> | ||
* Contactin-2 | * Contactin-2 | ||
| - | **[[5e7l]] – mCNTN FN1-FN3 domains – mouse <br/ > | ||
**[[2om5]] – hCNTN Ig1-Ig4 domains <br /> | **[[2om5]] – hCNTN Ig1-Ig4 domains <br /> | ||
| + | **[[5e7l]] – mCNTN FN1-FN3 domains – mouse <br/ > | ||
* Contactin-3 | * Contactin-3 | ||
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**[[5e4q]] – mCNTN FN1-FN3 domains <br /> | **[[5e4q]] – mCNTN FN1-FN3 domains <br /> | ||
**[[5i99]] – mCNTN Ig5-FN2 domains <br /> | **[[5i99]] – mCNTN Ig5-FN2 domains <br /> | ||
| - | **[[5e5r]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | + | **[[5e5r]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ <br /> |
| + | **[[7mrm]] – cCNTN FN1-FN2 domains + APPb<br /> | ||
* Contactin-4 | * Contactin-4 | ||
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**[[5e4s]] – mCNTN FN1-FN3 domains <br /> | **[[5e4s]] – mCNTN FN1-FN3 domains <br /> | ||
**[[3jxa]] – mCNTN Ig1-Ig4 domains <br /> | **[[3jxa]] – mCNTN Ig1-Ig4 domains <br /> | ||
| - | **[[3kld]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase | + | **[[3kld]] – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ <br /> |
| + | **[[7mrq]] – cCNTN FN1-FN3 domains <br /> | ||
| + | **[[7mro]] – zCNTN FN1-FN3 domains 600-903 – zebrafish<br /> | ||
| + | **[[7mrk]], [[7mrs]] – zCNTN FN1-FN3 domains + APPb<br /> | ||
| + | **[[7mqy]] – zCNTN FN1-FN3 domains + APLP2<br /> | ||
* Contactin-5 | * Contactin-5 | ||
| - | **[[5e4i]] – mCNTN Ig1-Ig4 domains <br /> | ||
**[[5e52]] – hCNTN FN1-FN3 domains <br /> | **[[5e52]] – hCNTN FN1-FN3 domains <br /> | ||
**[[4n68]] – hCNTN FN3 domains <br /> | **[[4n68]] – hCNTN FN3 domains <br /> | ||
| + | **[[5e4i]] – mCNTN Ig1-Ig4 domains 96-477 <br /> | ||
| + | **[[7mrn]] – mCNTN FN1-FN3 domains 669-970 + APP<br /> | ||
* Contactin-6 | * Contactin-6 | ||
Current revision
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3D structures of contactin
Updated on 30-November-2022
References
- ↑ Rush AM, Craner MJ, Kageyama T, Dib-Hajj SD, Waxman SG, Ranscht B. Contactin regulates the current density and axonal expression of tetrodotoxin-resistant but not tetrodotoxin-sensitive sodium channels in DRG neurons. Eur J Neurosci. 2005 Jul;22(1):39-49. PMID:16029194 doi:http://dx.doi.org/10.1111/j.1460-9568.2005.04186.x
- ↑ Cottrell CE, Bir N, Varga E, Alvarez CE, Bouyain S, Zernzach R, Thrush DL, Evans J, Trimarchi M, Butter EM, Cunningham D, Gastier-Foster JM, McBride KL, Herman GE. Contactin 4 as an autism susceptibility locus. Autism Res. 2011 Jun;4(3):189-99. doi: 10.1002/aur.184. Epub 2011 Feb 9. PMID:21308999 doi:http://dx.doi.org/10.1002/aur.184
