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5gw6

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==Water-Bridge Mediates Recognition of mRNA Cap in eIF4E==
==Water-Bridge Mediates Recognition of mRNA Cap in eIF4E==
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<StructureSection load='5gw6' size='340' side='right' caption='[[5gw6]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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<StructureSection load='5gw6' size='340' side='right'caption='[[5gw6]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gw6]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5abi 5abi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GW6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GW6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gw6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5abi 5abi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GW6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GW6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gw6 OCA], [http://pdbe.org/5gw6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gw6 RCSB], [http://www.ebi.ac.uk/pdbsum/5gw6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gw6 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gw6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gw6 OCA], [https://pdbe.org/5gw6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gw6 RCSB], [https://www.ebi.ac.uk/pdbsum/5gw6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gw6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN]] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
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[https://www.uniprot.org/uniprot/IF4E_HUMAN IF4E_HUMAN] Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.<ref>PMID:16271312</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5gw6" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5gw6" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brown, C J]]
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[[Category: Homo sapiens]]
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[[Category: Cap-dependent]]
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[[Category: Large Structures]]
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[[Category: Cap-free]]
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[[Category: Brown CJ]]
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[[Category: Translation]]
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Current revision

Water-Bridge Mediates Recognition of mRNA Cap in eIF4E

PDB ID 5gw6

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