5ukz
From Proteopedia
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(New page: '''Unreleased structure''' The entry 5ukz is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR Solution structure of chemically synthesized antilisterial Pediocin PA-1 M31L analog.== | |
| + | <StructureSection load='5ukz' size='340' side='right'caption='[[5ukz]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5ukz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pediococcus_acidilactici Pediococcus acidilactici]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UKZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ukz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ukz OCA], [https://pdbe.org/5ukz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ukz RCSB], [https://www.ebi.ac.uk/pdbsum/5ukz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ukz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPA1_PEDAC PPA1_PEDAC] Bactericidal activity (effective inhibitor of L.monocytogenes). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The antimicrobial peptide pediocin PA-1 is a class IIa bacteriocin that inhibits several clinically relevant pathogens including Listeria spp. Here we report the synthesis and characterization of whole pediocin PA-1 and novel analogs thereof using a combination of solid- and solution-phase strategies to overcome difficulties due to instability and undesired reactions. Pediocin PA-1 thus synthesized was a potent inhibitor of Listeria monocytogenes (MIC = 6.8 nM), similar to the bacteriocin produced naturally by Pediococcus acidilactici. Of particular interest is that linear analogs lacking both of the disulfide bridges characterizing pediocin PA-1 were as potent. One linear analog was also a strong inhibitor of Clostridium perfringens, another important food-borne pathogen. These results are discussed in light of conformational information derived from circular dichroism, solution NMR spectroscopy and structure-activity relationship studies. | ||
| - | + | Synthesis, antimicrobial activity and conformational analysis of the class IIa bacteriocin pediocin PA-1 and analogs thereof.,Bedard F, Hammami R, Zirah S, Rebuffat S, Fliss I, Biron E Sci Rep. 2018 Jun 13;8(1):9029. doi: 10.1038/s41598-018-27225-3. PMID:29899567<ref>PMID:29899567</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5ukz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pediococcus acidilactici]] | ||
| + | [[Category: Bedard F]] | ||
| + | [[Category: Biron E]] | ||
| + | [[Category: Fliss I]] | ||
| + | [[Category: Hammami R]] | ||
| + | [[Category: Rebuffat S]] | ||
| + | [[Category: Zirah S]] | ||
Current revision
NMR Solution structure of chemically synthesized antilisterial Pediocin PA-1 M31L analog.
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