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5x0m

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(New page: '''Unreleased structure''' The entry 5x0m is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (09:35, 23 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5x0m is ON HOLD
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==Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution==
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<SX load='5x0m' size='340' side='right' viewer='molstar' caption='[[5x0m]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x0m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Periplaneta_americana Periplaneta americana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X0M FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x0m OCA], [https://pdbe.org/5x0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x0m RCSB], [https://www.ebi.ac.uk/pdbsum/5x0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x0m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SCNA1_PERAM SCNA1_PERAM] Mediates the voltage-dependent sodium ion permeability of excitable membranes.[RuleBase:RU361132]<ref>PMID:28183995</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Voltage-gated sodium (Nav) channels are responsible for the initiation and propagation of action potentials. They are associated with a variety of channelopathies and are targeted by multiple pharmaceutical drugs and natural toxins. Here, we report the cryogenic electron microscopy structure of a putative Nav channel from American cockroach (designated NavPaS) at 3.8 angstrom resolution. The voltage-sensing domains (VSDs) of the four repeats exhibit distinct conformations. The entrance to the asymmetric selectivity filter vestibule is guarded by heavily glycosylated and disulfide bond-stabilized extracellular loops. On the cytoplasmic side, a conserved amino-terminal domain is placed below VSDI, and a carboxy-terminal domain binds to the III-IV linker. The structure of NavPaS establishes an important foundation for understanding function and disease mechanism of Nav and related voltage-gated calcium channels.
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Authors:
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Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution.,Shen H, Zhou Q, Pan X, Li Z, Wu J, Yan N Science. 2017 Mar 3;355(6328). pii: eaal4326. doi: 10.1126/science.aal4326. Epub , 2017 Feb 9. PMID:28183995<ref>PMID:28183995</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5x0m" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Periplaneta americana]]
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[[Category: Li Z]]
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[[Category: Pan X]]
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[[Category: Shen H]]
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[[Category: Wu J]]
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[[Category: Yan N]]
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[[Category: Zhou Q]]

Current revision

Structure of a eukaryotic voltage-gated sodium channel at near atomic resolution

5x0m, resolution 3.80Å

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