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5x1g

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'''Unreleased structure'''
 
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The entry 5x1g is ON HOLD
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==WHAMM's Microtubule binding motif==
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<SX load='5x1g' size='340' side='right' viewer='molstar' caption='[[5x1g]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5x1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5X1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5X1G FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5x1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5x1g OCA], [https://pdbe.org/5x1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5x1g RCSB], [https://www.ebi.ac.uk/pdbsum/5x1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5x1g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WHAMM_HUMAN WHAMM_HUMAN] Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration.<ref>PMID:18614018</ref> <ref>PMID:23027905</ref> <ref>PMID:23087206</ref>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Liu T]]
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[[Category: Wang HW]]

Current revision

WHAMM's Microtubule binding motif

5x1g, resolution 4.50Å

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