5ltw

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==Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6==
==Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6==
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<StructureSection load='5ltw' size='340' side='right' caption='[[5ltw]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
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<StructureSection load='5ltw' size='340' side='right'caption='[[5ltw]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LTW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ltw]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LTW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LTW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [http://pdbe.org/5ltw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [http://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ltw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ltw OCA], [https://pdbe.org/5ltw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ltw RCSB], [https://www.ebi.ac.uk/pdbsum/5ltw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ltw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ltw" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ltw" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Antson, A A]]
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[[Category: Homo sapiens]]
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[[Category: Beelen, S]]
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[[Category: Large Structures]]
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[[Category: Gusev, N B]]
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[[Category: Antson AA]]
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[[Category: Kulikova, A A]]
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[[Category: Beelen S]]
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[[Category: Sluchanko, N N]]
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[[Category: Gusev NB]]
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[[Category: Strelkov, S V]]
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[[Category: Kulikova AA]]
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[[Category: Weeks, S D]]
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[[Category: Sluchanko NN]]
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[[Category: Protein binding]]
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[[Category: Strelkov SV]]
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[[Category: Protein-protein complex]]
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[[Category: Weeks SD]]

Current revision

Complex of human 14-3-3 sigma CLU1 mutant with phosphorylated heat shock protein B6

PDB ID 5ltw

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