4r1i

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==Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps==
==Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps==
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<StructureSection load='4r1i' size='340' side='right' caption='[[4r1i]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
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<StructureSection load='4r1i' size='340' side='right'caption='[[4r1i]], [[Resolution|resolution]] 3.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r1i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R1I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R1I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r1i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae_FA19 Neisseria gonorrhoeae FA19]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R1I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R1I FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r0c|4r0c]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.959&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r1i OCA], [http://pdbe.org/4r1i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r1i RCSB], [http://www.ebi.ac.uk/pdbsum/4r1i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4r1i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r1i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r1i OCA], [https://pdbe.org/4r1i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r1i RCSB], [https://www.ebi.ac.uk/pdbsum/4r1i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r1i ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q9RNX2_NEIGO Q9RNX2_NEIGO]
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Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. N. gonorrhoeae MtrF is an integral membrane protein that belongs to the AbgT family of transporters for which no structural information is available. Here, we describe the crystal structure of MtrF, revealing a dimeric molecule with architecture distinct from all other families of transporters. MtrF is a bowl-shaped dimer with a solvent-filled basin extending from the cytoplasm to halfway across the membrane bilayer. Each subunit of the transporter contains nine transmembrane helices and two hairpins, posing a plausible pathway for substrate transport. A combination of the crystal structure and biochemical functional assays suggests that MtrF is an antibiotic efflux pump mediating bacterial resistance to sulfonamide antimetabolite drugs.
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Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps.,Su CC, Bolla JR, Kumar N, Radhakrishnan A, Long F, Delmar JA, Chou TH, Rajashankar KR, Shafer WM, Yu EW Cell Rep. 2015 Apr 7;11(1):61-70. doi: 10.1016/j.celrep.2015.03.003. Epub 2015, Mar 26. PMID:25818299<ref>PMID:25818299</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4r1i" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bolla, J R]]
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[[Category: Large Structures]]
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[[Category: Su, C C]]
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[[Category: Neisseria gonorrhoeae FA19]]
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[[Category: Yu, E W]]
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[[Category: Bolla JR]]
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[[Category: Membrane protein]]
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[[Category: Su C-C]]
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[[Category: Transmembrane protein]]
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[[Category: Yu EW]]

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Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps

PDB ID 4r1i

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