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1sbx

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[[Image:1sbx.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the Dachshund-homology domain of human SKI==
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|PDB= 1sbx |SIZE=350|CAPTION= <scene name='initialview01'>1sbx</scene>, resolution 1.65&Aring;
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<StructureSection load='1sbx' size='340' side='right'caption='[[1sbx]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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<table><tr><td colspan='2'>[[1sbx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SBX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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|GENE= SKI ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbx OCA], [https://pdbe.org/1sbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sbx RCSB], [https://www.ebi.ac.uk/pdbsum/1sbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sbx ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1sbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sbx OCA], [http://www.ebi.ac.uk/pdbsum/1sbx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1sbx RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SKI_HUMAN SKI_HUMAN] May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling.<ref>PMID:19049980</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of the Dachshund-homology domain of human SKI'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sb/1sbx_consurf.spt"</scriptWhenChecked>
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The nuclear protooncoprotein SKI negatively regulates transforming growth factor-beta (TGF-beta) signaling in cell growth and differentiation. It directly interacts with the Smads and, by various mechanisms, represses the transcription of TGF-beta-responsive genes. SKI is a multidomain protein that includes a domain bearing high sequence similarity with the retinal determination protein Dachshund (the Dachshund homology domain, DHD). The SKI-DHD has been implicated in SMAD-2/3, N-CoR, SKIP, and PML-RARalpha binding. The 1.65 A crystal structure of the Dachshund homology domain of human SKI is reported here. The SKI-DHD adopts a mixed alpha/beta structure which includes features found in the forkhead/winged-helix family of DNA binding proteins, although SKI-DHD is not a DNA binding domain. Residues that form a contiguous surface patch on SKI-DHD are conserved within the Ski/Sno family and with Dachshund, suggesting that this domain may mediate intermolecular interactions common to these proteins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Disease==
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</jmolCheckbox>
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Known disease associated with this structure: 1p36 deletion syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=164780 164780]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sbx ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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== References ==
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1SBX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SBX OCA].
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<references/>
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__TOC__
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==Reference==
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</StructureSection>
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Crystal structure of the dachshund homology domain of human SKI., Wilson JJ, Malakhova M, Zhang R, Joachimiak A, Hegde RS, Structure. 2004 May;12(5):785-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15130471 15130471]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hegde, R S.]]
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[[Category: Hegde RS]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: Malakhova, M.]]
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[[Category: Malakhova M]]
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[[Category: Wilson, J J.]]
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[[Category: Wilson JJ]]
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[[Category: Zhang, R.]]
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[[Category: Zhang R]]
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[[Category: forkhead]]
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[[Category: winged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:39:59 2008''
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Current revision

Crystal structure of the Dachshund-homology domain of human SKI

PDB ID 1sbx

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