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4nxp

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==Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM)==
==Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM)==
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<StructureSection load='4nxp' size='340' side='right' caption='[[4nxp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4nxp' size='340' side='right'caption='[[4nxp]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nxp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nxp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NXP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kzd|3kzd]], [[3kze|3kze]], [[4gvd|4gvd]], [[4gvc|4gvc]], [[4nxr|4nxr]], [[4nxq|4nxq]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxp OCA], [http://pdbe.org/4nxp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nxp RCSB], [http://www.ebi.ac.uk/pdbsum/4nxp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nxp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nxp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxp OCA], [https://pdbe.org/4nxp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nxp RCSB], [https://www.ebi.ac.uk/pdbsum/4nxp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nxp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
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[https://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fuentes, E J]]
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[[Category: Homo sapiens]]
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[[Category: Hengel, S R]]
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[[Category: Large Structures]]
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[[Category: Liu, X]]
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[[Category: Fuentes EJ]]
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[[Category: Shepherd, T R]]
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[[Category: Hengel SR]]
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[[Category: Speckhard, D C]]
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[[Category: Liu X]]
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[[Category: Beta barrel fold protein]]
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[[Category: Shepherd TR]]
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[[Category: Pdz domain]]
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[[Category: Speckhard DC]]
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[[Category: Peptide binding]]
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[[Category: Scaffold signaling protein for cell adhesion and cell junction]]
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[[Category: Signaling domain]]
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[[Category: Signaling protein]]
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[[Category: Specificity mutant]]
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Current revision

Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM)

PDB ID 4nxp

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