4mnb

<StructureSection load='4mnb' size='340' side='right' caption='[[4mnb]], [[Resolution|resolution]] 1.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[4mnb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MNB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4MNB FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene>, <scene name='pdbligand=VAR:9-AMINO-5-(2-AMINOPYRIMIDIN-4-YL)PYRIDO[3,2 4,5]PYRROLO[1,2-C]PYRIMIDIN-4-OL'>VAR</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mnb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mnb OCA], [http://pdbe.org/4mnb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4mnb RCSB], [http://www.ebi.ac.uk/pdbsum/4mnb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4mnb ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic effects is still unknown. The crystal structure of a variolin B bound to a DNA forming a pseudo-Holliday junction shows that this compound can also contribute, through intercalative binding, to either the formation or stabilization of multi-stranded DNA forms.

Intercalative DNA binding of the marine anticancer drug variolin B.,Canals A, Arribas-Bosacoma R, Albericio F, Alvarez M, Aymami J, Coll M Sci Rep. 2017 Jan 4;7:39680. doi: 10.1038/srep39680. PMID:28051169<ref>PMID:28051169</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 4mnb" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Albericio, F]]

[[Category: Alvarez, M]]

[[Category: Arribas-Bosacoma, R]]

[[Category: Aymami, J]]

[[Category: Canals, A]]

[[Category: Coll, M]]

[[Category: Nucleus]]