5hcl

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==Crystal Structure of the first bromodomain of BRD4 in complex with DMA==
==Crystal Structure of the first bromodomain of BRD4 in complex with DMA==
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<StructureSection load='5hcl' size='340' side='right' caption='[[5hcl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='5hcl' size='340' side='right'caption='[[5hcl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hcl]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HCL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hcl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HCL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5Y9:~{N},~{N}-DIMETHYLETHANAMIDE'>5Y9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcl OCA], [http://pdbe.org/5hcl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hcl RCSB], [http://www.ebi.ac.uk/pdbsum/5hcl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hcl ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5Y9:~{N},~{N}-DIMETHYLETHANAMIDE'>5Y9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hcl OCA], [https://pdbe.org/5hcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hcl RCSB], [https://www.ebi.ac.uk/pdbsum/5hcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hcl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5hcl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5hcl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Caflisch, A]]
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[[Category: Homo sapiens]]
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[[Category: Dong, J]]
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[[Category: Large Structures]]
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[[Category: Weber, F E]]
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[[Category: Caflisch A]]
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[[Category: Transcription-transcription inhibitor complex]]
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[[Category: Dong J]]
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[[Category: Weber FE]]

Current revision

Crystal Structure of the first bromodomain of BRD4 in complex with DMA

PDB ID 5hcl

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