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4nxr

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==Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide==
==Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide==
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<StructureSection load='4nxr' size='340' side='right' caption='[[4nxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4nxr' size='340' side='right'caption='[[4nxr]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nxr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NXR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NXR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANS:5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC+ACID(DANSYL+ACID)'>ANS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kzd|3kzd]], [[3kze|3kze]], [[4gvd|4gvd]], [[4gvc|4gvc]], [[4nxq|4nxq]], [[4nxp|4nxp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANS:5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC+ACID(DANSYL+ACID)'>ANS</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxr OCA], [http://pdbe.org/4nxr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4nxr RCSB], [http://www.ebi.ac.uk/pdbsum/4nxr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4nxr ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nxr OCA], [https://pdbe.org/4nxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nxr RCSB], [https://www.ebi.ac.uk/pdbsum/4nxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nxr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN]] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. [[http://www.uniprot.org/uniprot/NRX2B_HUMAN NRX2B_HUMAN]] Neuronal cell surface protein that may be involved in cell recognition and cell adhesion.
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[https://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fuentes, E J]]
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[[Category: Homo sapiens]]
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[[Category: Hengel, S R]]
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[[Category: Large Structures]]
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[[Category: Liu, X]]
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[[Category: Fuentes EJ]]
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[[Category: Shepherd, T R]]
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[[Category: Hengel SR]]
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[[Category: Speckhard, D C]]
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[[Category: Liu X]]
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[[Category: Beta barrel fold protein]]
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[[Category: Shepherd TR]]
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[[Category: Pdz domain]]
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[[Category: Speckhard DC]]
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[[Category: Peptide binding]]
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[[Category: Scaffold signaling protein for cell adhesion and cell junction]]
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[[Category: Signaling domain]]
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[[Category: Signaling protein-peptide complex]]
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[[Category: Specificity mutant]]
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Current revision

Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain Quadruple Mutant (QM) in Complex With Neurexin-1 Peptide

PDB ID 4nxr

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