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5t3u

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==Crystal Structure of the PTS IIA protein associated with the fucose utilization operon from Streptococcus pneumoniae==
==Crystal Structure of the PTS IIA protein associated with the fucose utilization operon from Streptococcus pneumoniae==
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<StructureSection load='5t3u' size='340' side='right' caption='[[5t3u]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
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<StructureSection load='5t3u' size='340' side='right'caption='[[5t3u]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5t3u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5T3U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5t3u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T3U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5t3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3u OCA], [http://pdbe.org/5t3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5t3u RCSB], [http://www.ebi.ac.uk/pdbsum/5t3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3u ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t3u OCA], [https://pdbe.org/5t3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t3u RCSB], [https://www.ebi.ac.uk/pdbsum/5t3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t3u ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/A0A0H2US38_STRPN A0A0H2US38_STRPN]
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Streptococcus pneumoniae harbors a significant number of transporters, including phosphotransferase (PTS) systems, allowing the bacterium to utilize a number of different carbohydrates for metabolic and other purposes. The genes encoding for one PTS transport system in particular (EIIfuc ) are found within a fucose utilization operon in S. pneumoniae TIGR4. Here, we report the 3-dimensional structures of IIAfuc and IIBfuc providing evidence that this PTS system belongs to the EIIman family. Additionally, the predicted metabolic pathway for this distinctive fucose utilization system suggests that EIIfuc transports the H-disaccharide blood group antigen, which would represent a novel PTS transporter specificity. This article is protected by copyright. All rights reserved.
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Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.,Higgins MA, Hamilton AM, Boraston AB Proteins. 2017 Feb 7. doi: 10.1002/prot.25264. PMID:28168775<ref>PMID:28168775</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5t3u" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boraston, A B]]
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[[Category: Large Structures]]
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[[Category: Higgins, M A]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Pt]]
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[[Category: Boraston AB]]
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[[Category: Transport]]
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[[Category: Higgins MA]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure of the PTS IIA protein associated with the fucose utilization operon from Streptococcus pneumoniae

PDB ID 5t3u

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