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2c2m

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==Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.==
==Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.==
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<StructureSection load='2c2m' size='340' side='right' caption='[[2c2m]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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<StructureSection load='2c2m' size='340' side='right'caption='[[2c2m]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c2m]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2C2M FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c2m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2M FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MX4:{1-[4-(BENZYLOXY)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX4</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cp3|1cp3]], [[1gfw|1gfw]], [[1i3o|1i3o]], [[1nme|1nme]], [[1nmq|1nmq]], [[1nms|1nms]], [[1pau|1pau]], [[1qx3|1qx3]], [[1re1|1re1]], [[1rhj|1rhj]], [[1rhk|1rhk]], [[1rhm|1rhm]], [[1rhq|1rhq]], [[1rhr|1rhr]], [[1rhu|1rhu]], [[2c1e|2c1e]], [[2c2k|2c2k]], [[2c2o|2c2o]], [[2cdr|2cdr]], [[2cjx|2cjx]], [[2cjy|2cjy]], [[2cnk|2cnk]], [[2cnl|2cnl]], [[2cnn|2cnn]], [[2cno|2cno]], [[2j30|2j30]], [[2j31|2j31]], [[2j32|2j32]], [[2j33|2j33]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MX4:{1-[4-(BENZYLOXY)-4-OXOBUTANOYL]HYDRAZINO}ACETIC+ACID'>MX4</scene>, <scene name='pdbligand=PHQ:BENZYL+CHLOROCARBONATE'>PHQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2m OCA], [http://pdbe.org/2c2m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2c2m RCSB], [http://www.ebi.ac.uk/pdbsum/2c2m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2m ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2m OCA], [https://pdbe.org/2c2m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2m RCSB], [https://www.ebi.ac.uk/pdbsum/2c2m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
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[https://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2m_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2m_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
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*[[Caspase|Caspase]]
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*[[Caspase 3D structures|Caspase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Asgian, J L]]
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[[Category: Homo sapiens]]
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[[Category: Campbell, A]]
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[[Category: Large Structures]]
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[[Category: Ekici, O D]]
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[[Category: Synthetic construct]]
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[[Category: Ganesan, R]]
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[[Category: Asgian JL]]
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[[Category: Gruetter, M G]]
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[[Category: Campbell A]]
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[[Category: James, K E]]
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[[Category: Ekici OD]]
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[[Category: Jelakovic, S]]
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[[Category: Ganesan R]]
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[[Category: Li, Z Z]]
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[[Category: Gruetter MG]]
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[[Category: Mikolajczyk, J]]
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[[Category: James KE]]
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[[Category: Powers, J C]]
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[[Category: Jelakovic S]]
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[[Category: Salvesen, G S]]
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[[Category: Li ZZ]]
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[[Category: Apoptosis]]
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[[Category: Mikolajczyk J]]
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[[Category: Aza-asp]]
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[[Category: Powers JC]]
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[[Category: Aza-peptide]]
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[[Category: Salvesen GS]]
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[[Category: Clan cd]]
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[[Category: Cpp32]]
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[[Category: Cysteine-protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Ice]]
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[[Category: Michael acceptor]]
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[[Category: Thiol protease]]
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[[Category: Yama]]
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[[Category: Zymogen]]
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Current revision

Crystal structures of caspase-3 in complex with aza-peptide Michael acceptor inhibitors.

PDB ID 2c2m

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